Evidence map›Paper›PMID 30601039›Full record

ReviewClimacteric : the journal of the International Menopause Society2019

The existence and potential of germline stem cells in the adult mammalian ovary.

E E Telfer, R A Anderson

Open access · hybridAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Climacteric : the journal of the International Menopause Society, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
3.8field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 32 citations in OpenAlex.

  1. Review
  2. Review
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  4. Article
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  7. Review
  8. Article
  9. The Role of the Guanosine Nucleotide-Binding Protein in the Corpus Luteum.Animals : an open access journal from MDPI · 2021
    Review
  10. Article
  11. Review
  12. Review
  13. Article
  14. Fertility Preservation in Women With Malignancy: Future Endeavors.Clinical medicine insights. Reproductive health · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

E E Telfera Institute of Cell Biology, School of Biological Sciences , University of Edinburgh , Edinburgh , UK.
R A Andersonb MRC Centre for Reproductive Health , Queen's Medical Research Institute, University of Edinburgh , Edinburgh , UK.
MRC Centre for Reproductive Health · GBUniversity of Edinburgh · GB

Funding

Medical Research Council G0901839Medical Research Council G1100357Medical Research Council MR/L00299X/1Medical Research Council MR/R003246/1
6 · The paper itself

Abstract

It has long been accepted that the complement of follicles within the ovary is formed before birth in humans, or shortly after birth in rodents, and that no follicles are formed thereafter. This follows entry of all oogonia into meiosis in fetal life, with no remaining germ stem cells in the ovary, in contrast to the presence of spermatogonia in the testis. This has been brought back into debate in recent years, following the demonstration of isolation of cells expressing both germline and stem markers from the postnatal ovary in several species, including humans. We describe these cells as putative ovarian stem cells. Isolation of these cells is challenging, adding to the debate as to their existence, and the validity of DDX4 as the main marker used for their isolation has also to be questioned. While different groups have used varying techniques and indeed terminology to describe these cells, the body of evidence regarding their initial characterization after isolation is growing. There remain very limited data regarding their developmental potential, but the demonstration of the production of functional oocytes from induced pluripotent stem cells and the advances in ovarian follicle culture techniques provide a basis for such studies.

Indexed as

OogenesisAdult Germline Stem CellsAnimalsFemaleHumansOocytesOogonial Stem CellsOvarian FollicleOvaryneo-oogenesisoocyteOogonial stem cellsovarian regeneration

Identifiers

PMID30601039
PMCPMC6364305
OpenAlexW2907970864

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.