Evidence map›Paper›PMID 30600998›Full record

ArticleJournal of natural products2019

Secondary Metabolites from the Fungus Dictyosporium sp. and Their MALT1 Inhibitory Activities.

Trong D Tran, Brice A P Wilson, Curtis J Henrich, Louis M Staudt, Lauren R H Krumpe, Emily A Smith, Jarrod King, Karen L Wendt, Alberto M Stchigel, Andrew N Miller and 3 more

Abstract read
In one paragraph

Article in Journal of natural products, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Natural Products as a Foundation for Drug Discovery.Current protocols in pharmacology · 2019
    Review
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Trong D TranMolecular Targets Program, Center of Cancer Research , National Cancer Institute , Frederick , Maryland 21701-1201 , United States.
Brice A P WilsonMolecular Targets Program, Center of Cancer Research , National Cancer Institute , Frederick , Maryland 21701-1201 , United States.
Curtis J HenrichMolecular Targets Program, Center of Cancer Research , National Cancer Institute , Frederick , Maryland 21701-1201 , United States.
Louis M StaudtLymphoid Malignancies Branch, Center for Cancer Research , National Cancer Institute , Bethesda , Maryland 20892 , United States.
Lauren R H KrumpeMolecular Targets Program, Center of Cancer Research , National Cancer Institute , Frederick , Maryland 21701-1201 , United States.
Emily A SmithMolecular Targets Program, Center of Cancer Research , National Cancer Institute , Frederick , Maryland 21701-1201 , United States.
Jarrod KingNatural Products Discovery Group, Department of Chemistry and Biochemistry , University of Oklahoma , Norman , Oklahoma 73019-5251 , United States.
Karen L WendtNatural Products Discovery Group, Department of Chemistry and Biochemistry , University of Oklahoma , Norman , Oklahoma 73019-5251 , United States.
Alberto M StchigelMycology Unit , Universitat Rovira i Virgili , C/Sant Llorenç 21 , 43201 Reus , Spain.
Andrew N MillerIllinois Natural History Survey , University of Illinois , 1816 South Oak Street , Champaign , Illinois 61820-6970 , United States.
Robert H CichewiczNatural Products Discovery Group, Department of Chemistry and Biochemistry , University of Oklahoma , Norman , Oklahoma 73019-5251 , United States.ORCID 0000-0003-0744-4117
Barry R O'KeefeMolecular Targets Program, Center of Cancer Research , National Cancer Institute , Frederick , Maryland 21701-1201 , United States.ORCID 0000-0003-0772-4856
Kirk R GustafsonMolecular Targets Program, Center of Cancer Research , National Cancer Institute , Frederick , Maryland 21701-1201 , United States.ORCID 0000-0001-6821-4943

Funding

Natural Products Discovery and Characterization Through Network CollaborationsZIABC011568 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI DU, LIN · 2014 to 2025
$17.2M
New Leads for Triple Negative Breast Cancer from Diverse Natural SourcesU01CA182740 · NCI · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI CICHEWICZ, ROBERT HENRY, MOOBERRY, SUSAN L · 2014 to 2018
$2.3M
CCR NIH HHS HHSN261200800001CIntramural NIH HHS ZIA BC011568NCI NIH HHS HHSN261200800001ENCI NIH HHS U01 CA182740
6 · The paper itself

Abstract

Bioassay-guided separation of an extract from a Dictyosporium sp. isolate led to the identification of six new compounds, 1-6, together with five known compounds, 7-11. The structures of the new compounds were primarily established by extensive 1D and 2D NMR experiments. The absolute configurations of compounds 3-6 were determined by comparison of their experimental electronic circular dichroism (ECD) spectra with DFT quantum mechanical calculated ECD spectra. Compounds 3-5 possess novel structural scaffolds, and biochemical studies revealed that oxepinochromenones 1 and 7 inhibited the activity of MALT1 protease.

Indexed as

Enzyme InhibitorsFungiMucosa-Associated Lymphoid Tissue Lymphoma Translocation 1 ProteinEnzyme InhibitorsMucosa-Associated Lymphoid Tissue Lymphoma Translocation 1 Protein

Identifiers

PMID30600998
PMCPMC7462088

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.