ArticleWorld psychiatry : official journal of the World Psychiatric Association (WPA)2019
Transdiagnostic dimensions of psychosis in the Bipolar-Schizophrenia Network on Intermediate Phenotypes (B-SNIP).
Article in World psychiatry : official journal of the World Psychiatric Association (WPA), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05130853 (Social Cognition Individualized Activities Lab), which is not on this map. Cited by 78 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Social Cognition Individualized Activities Lab (SoCIAL) for the Training of Social Cognition and Narrative Enhancement in Patients With Schizophrenia: A Randomized Controlled Study to Assess Efficacy and Generalization to Real-life Functioning
Who cites it
78 citing papers in PubMed, 4 syntheses or guidelines pooled it, 134 citations in OpenAlex.
- Comorbid Schizophrenia and Psychotic Symptoms in Patients With Bipolar Disorder: A Meta-Analysis of the Global Literature.Bipolar disorders · 2026Pooled it
- The hierarchical taxonomy of psychopathology and the search for neurobiological substrates of mental illness: A systematic review and roadmap for future research.Journal of psychopathology and clinical science · 2024Pooled it
- Neuropsychological Performance Among Individuals at Clinical High-Risk for Psychosis vs Putatively Low-Risk Peers With Other Psychopathology: A Systematic Review and Meta-Analysis.Schizophrenia bulletin · 2022Pooled it
- Narrative identity in the psychosis spectrum: A systematic review and developmental model.Clinical psychology review · 2021Pooled it
- Effects of a Novel, Transdiagnostic Ecological Momentary Intervention for Prevention, and Early Intervention of Severe Mental Disorder in Youth (EMIcompass): Findings From an Exploratory Randomized Controlled Trial.Schizophrenia bulletin · 2023Trial
- How to improve the physical health of people with severe mental illness? A multicentric randomized controlled trial on the efficacy of a lifestyle group intervention.European psychiatry : the journal of the Association of European Psychiatrists · 2021Trial
- Article
- Polygenic associations with phenotypic classes across the psychosis-affective spectrum.medRxiv : the preprint server for health sciences · 2026Article
- Neural Responses to Reward and Psychosis Dimensions.Schizophrenia bulletin · 2026Article
- Modeling Negative Symptom Domain Neurobiology: Protocol for an Observational, Transdiagnostic, Translational Study.JMIR research protocols · 2026Observational
- Excessive gamma and beta oscillations in manic states across mood and psychotic disorders.Scientific reports · 2026Article
- Two Sides of One Coin: Affective Psychosis vs. Non-Affective Psychosis in Teenagers.Children (Basel, Switzerland) · 2026Article
- Latent class analysis of symptoms across schizophrenia, schizoaffective disorder, and bipolar I disorder.medRxiv : the preprint server for health sciences · 2025Article
- Three Distinct Pathways to First Episode Mania and Psychosis: Latent Class Analysis of Antecedent Psychopathology.Acta psychiatrica Scandinavica · 2025Article
- The Borderline Symptom List-Interview: development and psychometric evaluation of an observer-based instrument for assessing symptom severity in borderline personality disorder.Borderline personality disorder and emotion dysregulation · 2025Article
- Differentiating biomarker features and familial characteristics of B-SNIP psychosis Biotypes.Translational psychiatry · 2025Article
- Transdiagnostic Symptom Dimensions in Individuals at Ultra-High Risk for Psychosis: Towards Dimensional Representations of Pluripotent Risk.Early intervention in psychiatry · 2025Article
- Detecting schizophrenia, bipolar disorder, psychosis vulnerability and major depressive disorder from 5 minutes of online-collected speech.Translational psychiatry · 2025Article
- The Common Structure of the Major Psychoses: More Similarities Than Differences in the Network Structures of Schizophrenia, Schizoaffective Disorder, and Psychotic Bipolar Disorder.Schizophrenia bulletin · 2025Article
- Are dissociative psychosis and dissociative schizophrenia reality?World journal of psychiatry · 2025Article
18 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 9 institutions in 4 countries.
Funding
Abstract
The validity of the classification of non-affective and affective psychoses as distinct entities has been disputed, but, despite calls for alternative approaches to defining psychosis syndromes, there is a dearth of empirical efforts to identify transdiagnostic phenotypes of psychosis. We aimed to investigate the validity and utility of general and specific symptom dimensions of psychosis cutting across schizophrenia, schizoaffective disorder and bipolar I disorder with psychosis. Multidimensional item-response modeling was conducted on symptom ratings of the Positive and Negative Syndrome Scale, Young Mania Rating Scale, and Montgomery-Åsberg Depression Rating Scale in the multicentre Bipolar-Schizophrenia Network on Intermediate Phenotypes (B-SNIP) consortium, which included 933 patients with a diagnosis of schizophrenia (N=397), schizoaffective disorder (N=224), or bipolar I disorder with psychosis (N=312). A bifactor model with one general symptom dimension, two distinct dimensions of non-affective and affective psychosis, and five specific symptom dimensions of positive, negative, disorganized, manic and depressive symptoms provided the best model fit. There was further evidence on the utility of symptom dimensions for predicting B-SNIP psychosis biotypes with greater accuracy than categorical DSM diagnoses. General, positive, negative and disorganized symptom dimension scores were higher in African American vs. Caucasian patients. Symptom dimensions accurately classified patients into categorical DSM diagnoses. This study provides evidence on the validity and utility of transdiagnostic symptom dimensions of psychosis that transcend traditional diagnostic boundaries of psychotic disorders. Findings further show promising avenues for research at the interface of dimensional psychopathological phenotypes and basic neurobiological dimensions of psychopathology.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.