Evidence map›Paper›PMID 30600580›Full record

ReviewEuropean journal of heart failure2019

The use of diuretics in heart failure with congestion - a position statement from the Heart Failure Association of the European Society of Cardiology.

Wilfried Mullens, Kevin Damman, Veli-Pekka Harjola, Alexandre Mebazaa, Hans-Peter Brunner-La Rocca, Pieter Martens, Jeffrey M Testani, W H Wilson Tang, Francesco Orso, Patrick Rossignol and 5 more

4 registry-linked trialsOpen access · bronzeAbstract readReviewConsensus Statement
PubMed Publisher
In one paragraph

Review in European journal of heart failure, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 4 registered trials, which are not on this map. Cited by 478 papers, 15 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
478citing papers in PubMed, 15 pooled it
70.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04331132 naunknown statusnot on this mapstarted 2021, after this paper: background citation

Tolvaptan add-on Therapy to Overcome Loop Diuretic Resistance in Acute Heart Failure With Renal Dysfunction

TypeinterventionalSponsorGia Dinh People HospitalRan2021 to 2023Enrolled128ConditionsAcute Heart FailureArmsTolvaptan 15 MG
NCT06414759 phase4unknown statusnot on this mapstarted 2024, after this paper: background citation

Efficacy and Safety of Combination Diuretic Therapy in Patients With Acute Decompensated Heart Failure and Volume Overload

TypeinterventionalSponsorCairo UniversityRan2024 to 2025Enrolled110ConditionsAcute Decompensated Heart Failure, Volume Overload, EdemaArmsAcetazolamide, Metolazone, IV Loop Diuretics
NCT06495892 phase4recruitingnot on this mapstarted 2024, after this paper: background citation

Peripheral Venous Pressure-Guided Decongestive Therapy in Heart Failure 2

TypeinterventionalSponsorBaşakşehir Çam & Sakura City HospitalRan2024 to 2026Enrolled650ConditionsHeart Failure, Congestion, Congestive Heart FailureArmsDiuretic therapy
NCT07631780 nanot yet recruitingnot on this mapstarted 2026, after this paper: background citation

Urinary Sodium-Guided Optimization of Diuretic Therapy in Patients With Worsening Heart Failure: Rationale and Design of a Pragmatic Randomized Controlled Trial (SURE-HF Trial)

TypeinterventionalSponsorNurgul AblakimovaRan2026 to 2027Enrolled260ConditionsWorsening Heart Failure, Congestion, Heart FailureArmsFurosemide, Horiba LAQUAtwin B-722
3 · Its place in the literature

Who cites it

478 citing papers in PubMed, 15 syntheses or guidelines pooled it, 1,028 citations in OpenAlex.

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  6. Sample Size of Trials Investigating the Impact of Point-of-Care Ultrasound-Guided Strategies on Patient Outcomes: A Systematic Review.Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine · 2025
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  11. Subcutaneous furosemide in heart failure: a systematic review.European heart journal. Cardiovascular pharmacotherapy · 2025
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418 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors at 15 institutions in 10 countries.

Wilfried MullensZiekenhuis Oost Limburg, Genk, Belgium.
Kevin DammanUniversity of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Veli-Pekka HarjolaEmergency Medicine, University of Helsinki, Helsinki University Hospital, Helsinki, Finland.
Alexandre MebazaaUniversity of Paris Diderot, Hôpitaux Universitaires Saint Louis Lariboisière, APHP, U 942 Inserm, F-CRIN INI-CRCT, Paris, France.
Hans-Peter Brunner-La RoccaMaastricht University Medical Center, Maastricht, The Netherlands.
Pieter MartensZiekenhuis Oost Limburg, Genk, Belgium.
Jeffrey M TestaniYale University, New Haven, CT, USA.
W H Wilson TangCleveland Clinic, Cleveland, OH, USA.
Francesco OrsoUniversity of Florence, Florence, Italy.
Patrick RossignolUniversité de Lorraine, Inserm, Centre d'Investigations Clinique 1433 and Inserm U1116; CHRU Nancy; F-CRIN INI-CRCT, Nancy, France.
Marco MetraUniversity of Brescia, Brescia, Italy.
Gerasimos FilippatosNational and Kapodistrian University of Athens, Athens, Greece.
Petar M SeferovicUniversity of Belgrade, Faculty of Medicine, Belgrade, Serbia.
Frank RuschitzkaUniversitätsSpital Zürich, Zürich, Switzerland.
Andrew J CoatsIRCCS, San Raffaele Pisana, Rome, Italy.
Centre d’Investigation Clinique 1436Cleveland Clinic · USDélégation Paris 7 · FRHasselt University · BEHelsinki University Hospital · FIIRCCS Ospedale San Raffaele · ITMaastricht University · NLNational and Kapodistrian University of Athens · GRSee-Spital · CHUniversity of Belgrade · RSUniversity of Brescia · ITUniversity of Florence · ITUniversity of Groningen · NLYale University · USZiekenhuis Oost-Limburg · BE

Funding

Nitrative stress in heart failureR01HL103931 · NHLBI · CLEVELAND CLINIC LERNER COM-CWRU · PI TANG, WAI HONG WILSON · 2010 to 2014
$3.8M
NHLBI NIH HHS R01 HL103931
6 · The paper itself

Abstract

The vast majority of acute heart failure episodes are characterized by increasing symptoms and signs of congestion with volume overload. The goal of therapy in those patients is the relief of congestion through achieving a state of euvolaemia, mainly through the use of diuretic therapy. The appropriate use of diuretics however remains challenging, especially when worsening renal function, diuretic resistance and electrolyte disturbances occur. This position paper focuses on the use of diuretics in heart failure with congestion. The manuscript addresses frequently encountered challenges, such as (i) evaluation of congestion and clinical euvolaemia, (ii) assessment of diuretic response/resistance in the treatment of acute heart failure, (iii) an approach towards stepped pharmacologic diuretic strategies, based upon diuretic response, and (iv) management of common electrolyte disturbances. Recommendations are made in line with available guidelines, evidence and expert opinion.

Indexed as

CardiologyConsensusSocieties, MedicalDiureticsEuropeHeart FailureHumansStroke VolumeDiureticsAcute heart failureDiureticsHeart failureLoop diureticsPharmacotherapy

Identifiers

PMID30600580
OpenAlexW2907983377

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.