Evidence map›Paper›PMID 30600571›Full record

ReviewHuman brain mapping2019

Critical role of glutamatergic and GABAergic neurotransmission in the central mechanisms of theta-burst stimulation.

Cheng-Ta Li, Ying-Zu Huang, Ya-Mei Bai, Shih-Jen Tsai, Tung-Ping Su, Chih-Ming Cheng

Registry-linked trialAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Human brain mapping, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07049211 (Individualized Closed-Loop Neuromodulation With Repetitive Transcranial Magnetic Stimulation Synchronized Task Training for Upper Limb Motor Dysfunction in Stroke Patients), which is not on this map. Cited by 43 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07049211 nanot yet recruitingnot on this mapstarted 2025, after this paper: background citation

Individualized Closed-Loop Neuromodulation With Repetitive Transcranial Magnetic Stimulation Synchronized Task Training for Upper Limb Motor Dysfunction in Stroke Patients

TypeinterventionalSponsorRuijin HospitalRan2025 to 2028Enrolled51ConditionsUpper Extremity Dysfunction After the StrokeArmsIndividualized online stimulation, Non-individualized online stimulation, Sham stimulation
3 · Its place in the literature

Who cites it

43 citing papers in PubMed, 4 syntheses or guidelines pooled it.

  1. Pooled it
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  12. Review
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  17. The effects of intermittent theta burst stimulation (iTBS) on resting-state brain entropy (BEN).Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Cheng-Ta LiDepartment of Psychiatry, Taipei Veterans General Hospital, Taipei, Taiwan.ORCID 0000-0002-0670-1153
Ying-Zu HuangDepartment of Medicine, School of Medicine, Chang Gung University, Taoyuan City, Taiwan.
Ya-Mei BaiDepartment of Psychiatry, Taipei Veterans General Hospital, Taipei, Taiwan.
Shih-Jen TsaiDepartment of Psychiatry, Taipei Veterans General Hospital, Taipei, Taiwan.
Tung-Ping SuDepartment of Psychiatry, Taipei Veterans General Hospital, Taipei, Taiwan.
Chih-Ming ChengDepartment of Psychiatry, Taipei Veterans General Hospital, Taipei, Taiwan.

Funding

Ministry of Science and Technology MOST103-2314-B-075-072-MY3Ministry of Science and Technology MOST103-2314-B-075-072-MY3, MOST106-2314-B-075-034Ministry of Science and Technology MOST106-2314-B-075-034-MY3National Yang-Ming University 107BRC-B504Taipei Veterans General Hospital V106C-043Taipei Veterans General Hospital V107C-123
6 · The paper itself

Abstract

Theta-burst stimulation (TBS) is a varied form of repetitive transcranial magnetic stimulation (rTMS) and has more rapid and powerful effects than rTMS. Experiments on the human motor cortex have demonstrated that intermittent TBS has facilitatory effects, whereas continuous TBS has inhibitory effects. Huang's simplified model provides a solid basis for elucidating such after-effects. However, evidence increasingly indicates that not all after-effects of TBS are as expected, and high variability among individuals has been observed. Studies have suggested that the GABAergic and glutamatergic neurotransmission play a vital role in the aforementioned after-effects, which might explain the interindividual differences in these after-effects. Herein, we reviewed the latest findings on TBS from animal and human experiments on glutamatergic and GABAergic neurotransmissions in response to TBS. Furthermore, an updated theoretical model integrating glutamatergic and GABAergic neurotransmissions is proposed.

Indexed as

GABAergic NeuronsGlutamic AcidHumansMotor CortexNeuronsSynaptic TransmissionTheta RhythmTranscranial Magnetic StimulationGlutamic AcidGABAglutamatemechanismsrepetitive transcranial magnetic stimulationtheta-burst stimulation

Identifiers

PMID30600571
PMCPMC6865436

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.