Evidence map›Paper›PMID 30600520›Full record

ArticleMaternal and child health journal2019

Maternal Metabolic Complications in Pregnancy and Offspring Behavior Problems at 2 Years of Age.

John E Krzeczkowski, Amanda Lau, Jennifer Fitzpatrick, Sukhpreet Tamana, Lisa Smithson, Russell de Souza, Anita L Kozyrskyj, Diana Lefebvre, Allan B Becker, Padmaja Subbarao and 7 more

Abstract read
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In one paragraph

Article in Maternal and child health journal, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
3.6field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 21 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 5 institutions in 1 country.

John E KrzeczkowskiNeuroscience Graduate Program, McMaster University, Hamilton, ON, Canada.
Amanda LauDepartment of Pediatrics, University of Alberta, Edmonton, AB, Canada.
Jennifer FitzpatrickDepartment of Pediatrics, University of Alberta, Edmonton, AB, Canada.
Sukhpreet TamanaDepartment of Pediatrics, University of Alberta, Edmonton, AB, Canada.
Lisa SmithsonDepartment of Pediatrics, University of Alberta, Edmonton, AB, Canada.
Russell de SouzaDepartment of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, ON, Canada.
Anita L KozyrskyjDepartment of Pediatrics, University of Alberta, Edmonton, AB, Canada.
Diana LefebvreDepartment of Medicine, McMaster University, Hamilton, ON, Canada.
Allan B BeckerManitoba Institute of Child Health, University of Manitoba, Winnipeg, MB, Canada.
Padmaja SubbaraoDepartment of Pediatrics, University of Toronto, Toronto, ON, Canada.
Stuart E TurveyDepartment of Pediatrics, University of British Columbia, Vancouver, BC, Canada.
Jacqueline PeiDepartment of Educational Psychology, University of Alberta, Edmonton, AB, Canada.
Louis A SchmidtDepartment of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, ON, Canada.
Malcolm R SearsDepartment of Medicine, McMaster University, Hamilton, ON, Canada.
Ryan J Van LieshoutDepartment of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, ON, Canada.
Piush J MandhaneDepartment of Pediatrics, University of Alberta, Edmonton, AB, Canada. mandhane@ualberta.ca.
CHILD Study Investigators
University of Alberta · CAMcMaster University · CAUniversity of British Columbia · CAChildren's Hospital Research Institute of Manitoba · CAUniversity of Toronto · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objectives Prenatal maternal metabolic problems such as pre-pregnancy adiposity, excess gestational weight gain, and gestational diabetes mellitus (GDM) are associated with an increased risk of psychopathology in offspring. We examined whether these exposures were linked to symptoms of emotional and behavioral problems in offspring at 2 years of age, or if associations were due to confounding variables. Methods Data from 815 mother-child pairs enrolled at the Edmonton site of the Canadian Healthy Infant Longitudinal Development cohort were used to examine associations between gestational metabolic complications and scores on the externalizing and internalizing scales of the Child Behavior Checklist (CBCL-1½ to 5) at age two. Associations between maternal metabolic complications and offspring psychopathology were assessed before and after adjustment for gestational diet, socioeconomic status (SES), postpartum depression (PPD), prenatal smoking and breastfeeding. Results Pre-pregnancy body mass index and GDM, but not gestational weight gain, predicted more offspring externalizing and internalizing problems. However, after adjustment for confounding variables, these associations were no longer statistically significant. Post-hoc analyses revealed that gestational diet accounted for unique variance in both externalizing (semi-partial r

Indexed as

PsychopathologyAdiposityAdultBlood GlucoseBody Mass IndexCanadaChecklistChildChild BehaviorChild Behavior DisordersChild, PreschoolCohort StudiesDiabetes, GestationalFemaleHumansInfantBlood GlucoseChild Behavior ChecklistGestational diabetes mellitusObesityPrenatal nutritionPrenatal programmingPreschool

Identifiers

PMID30600520
OpenAlexW2906994704

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.