ArticleThe journal of physiological sciences : JPS2019
Effects of nicotine on odor-induced increases in regional blood flow in the olfactory bulb in rats.
Article in The journal of physiological sciences : JPS, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 11 citations in OpenAlex.
- Cerebral Blood Flow Responses to Trigeminal Olfactory Stimulation and Their Nicotinic Cholinergic Regulation in Anesthetized Rats.The European journal of neuroscience · 2025Article
- Influence of age on nicotinic cholinergic regulation of blood flow in rat's olfactory bulb and neocortex.The journal of physiological sciences : JPS · 2024Review
- Cerebral Cortical Vasodilation via Nicotinic Receptors by Heated Tobacco Product Aerosol Extract in Rats.Journal of vascular research · 2024Article
- Nicotinic cholinergic regulation of olfactory bulb blood flow response in aged rats.The journal of physiological sciences : JPS · 2023Article
- Article
- Olfactory function and discrimination ability in the elderly: a pilot study.The journal of physiological sciences : JPS · 2022Article
- The relationship between olfaction and cognitive function in the elderly.The journal of physiological sciences : JPS · 2020Article
- Effects of nicotine on regional blood flow in the olfactory bulb in response to olfactory nerve stimulation.The journal of physiological sciences : JPS · 2020Article
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3 authors at 1 institution in 1 country.
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Abstract
The present study examined the effects of nicotinic acetylcholine receptor activation on the odor-induced blood flow response in the olfactory bulb. In urethane-anesthetized rats, odor stimulation (5% amyl acetate, 30 s) produced an increase in olfactory bulb blood flow (reaching 107% ± 3% of the pre-stimulus basal values), without changes in frontal cortical blood flow or mean arterial pressure. Intravenous injection of nicotine (30 μg/kg), a nicotinic acetylcholine receptor agonist, significantly augmented the odor-induced increase response of olfactory bulb blood flow, without changes in the basal blood flow level. The nicotine-induced augmentation of the olfactory bulb blood flow response to odor was negated by dihydro-β-erythroidine, an α4β2-preferring nicotinic acetylcholine receptor antagonist. Our results suggest that the activation of α4β2-like neuronal nicotinic acetylcholine receptors in the brain potentiates an odor-induced blood flow response in the olfactory bulb.
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