Evidence map›Paper›PMID 30600434›Full record

ArticleJournal of endocrinological investigation2019

Comparative study of testosterone and vitamin D analogue, elocalcitol, on insulin-controlled signal transduction pathway regulation in human skeletal muscle cells.

C Antinozzi, F Marampon, P Sgrò, V Tombolini, A Lenzi, C Crescioli, L Di Luigi

Abstract readComparative Study
PubMed Publisher
In one paragraph

Article in Journal of endocrinological investigation, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Review
  6. Vitamin D, sport and health: a still unresolved clinical issue.Journal of endocrinological investigation · 2020
    Review
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

C AntinozziUnit of Endocrinology, Department of Movement, Human and Health Sciences, University of Rome "Foro Italico", 00135, Rome, Italy.
F MaramponUnit of Endocrinology, Department of Movement, Human and Health Sciences, University of Rome "Foro Italico", 00135, Rome, Italy.
P SgròUnit of Endocrinology, Department of Movement, Human and Health Sciences, University of Rome "Foro Italico", 00135, Rome, Italy.
V TomboliniDepartment of Radiotherapy, Sapienza University of Rome, Rome, Italy.
A LenziDepartment of Experimental Medicine, Sapienza University of Rome, Rome, Italy.
C CrescioliUnit of Endocrinology, Department of Movement, Human and Health Sciences, University of Rome "Foro Italico", 00135, Rome, Italy. clara.crescioli@uniroma4.it.
L Di LuigiUnit of Endocrinology, Department of Movement, Human and Health Sciences, University of Rome "Foro Italico", 00135, Rome, Italy.
Foro Italico University of Rome · ITSapienza University of Rome · IT

Funding

Ministero dell'Istruzione, dell'Università e della Ricerca 2010C8ERKX_002
6 · The paper itself

Abstract

purposeSkeletal muscle (Skm) plays a key role in regulating energetic metabolism through glucose homeostasis. Several hormones such as Testosterone (T) and Vitamin D (VD) have been shown to affect energy-dependent cell trafficking by determining Insulin (I)-like effects.

aimTo elucidate possible hormone-related differences on muscular metabolic control, we analyzed and compared the effects of T and elocalcitol (elo), a VD analogue, on the activation of energy-dependent cell trafficking, metabolism-related-signal transduction pathways and transcription of gene downstream targets.

methodsHuman fetal skeletal muscle cells (Hfsmc) treated with T or elo were analyzed for GLUT4 localization, phosphorylation/activation status of AKT, ERK1/2, IRS-1 signaling and c-MYC protein expression.

resultsT, similar to elo, induced GLUT4 protein translocation likely in lipid raft microdomains. While both T and elo induced a rapid IRS-1 phosphorylation, the following dynamic in phosphorylation/activation of AKT and ERK1/2 signaling was different. Moreover, T but not elo increased c-MYC protein expression.

conclusionsAll together, our evidence indicates that whether both T and elo are able to affect upstream I-like pathway, they differently determine downstream effects in I-dependent cascade, suggesting diverse physiological roles in mediating I-like response in human skeletal muscle.

Indexed as

AndrogensCalcitriolCells, CulturedHumansHypoglycemic AgentsInsulinMaleMuscle, SkeletalSignal TransductionTestosteroneAndrogensBXL628CalcitriolHypoglycemic AgentsInsulinTestosteroneElocalcitolHuman skeletal muscle cellsInsulinMetabolismTestosterone

Identifiers

PMID30600434
OpenAlexW2908445479

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.