Evidence map›Paper›PMID 30600432›Full record

ArticleJournal of molecular neuroscience : MN2019

Possible Metabolic Alterations among Autistic Male Children: Clinical and Biochemical Approaches.

Mohammed H Hassan, Tarek Desoky, Hala M Sakhr, Romany H Gabra, Ali Helmi Bakri

Abstract read
PubMed Publisher
In one paragraph

Article in Journal of molecular neuroscience : MN, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 5 pooled it
3.8field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 5 syntheses or guidelines pooled it, 59 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Article
  7. Review
  8. Article
  9. Rodent Models for ASD Biomarker Development.Advances in neurobiology · 2024
    Review
  10. Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Review
  20. Increased iron content in the heart of the Fmr1 knockout mouse.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Mohammed H HassanDepartment of Medical Biochemistry, Faculty of Medicine, South Valley University, Qena, Egypt. Mohammedhosnyhassaan@yahoo.com.ORCID http://orcid.org/0000-0003-2698-9438
Tarek DesokyDepartment of Neuropsychiatry, Faculty of Medicine, South Valley University, Qena, Egypt.
Hala M SakhrDepartment of Pediatrics, Faculty of Medicine, South Valley University, Qena, Egypt.
Romany H GabraDepartment of Neuropsychiatry, Faculty of Medicine, Assiut University, Assiut, Egypt.
Ali Helmi BakriDepartment of Pediatrics, Faculty of Medicine, South Valley University, Qena, Egypt.
South Valley University · EGAssiut University · EG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The present cross-sectional, hospital-based study was carried out on 146 Egyptian male children, 73 males with autism who were comparable with another 73 healthy age- and sex-matched children, recruited from the outpatients' psychiatric clinics of the Neuropsychiatric and Pediatric Departments of South Valley and Assiut University Hospitals, Egypt. Neuropsychological assessments of autistic males were done using CARS, short sensory profile and intelligent quotients. Serum markers of mitochondrial dysfunction (lactate, pyruvate, and lactate to pyruvate ratio, creatine kinase (CK), L-carnitine, ammonia, lactate dehydrogenase, pyruvate kinase, alanine transaminase and aspartate transaminase), oxidative stress and blood levels of heavy metals (mercury, lead and aluminium) were measured. Serum cholesterol, cortisol, free testosterone, estradiol, dehydroepiandrostenedione, adenosine deaminase and Helicobacter pylori antigen in stool were also performed. There was evidence of mitochondrial dysfunction among autistic children. Additionally, there were significantly lower serum total cholesterol, cortisol and estradiol as well as significantly higher dehydroepiandrostenedione (DHEA) and free testosterone (p < 0.05 for all markers). Twenty-eight (38%) cases were positive for H. pylori antigen in their stool with significant higher serum ammonia and lower adenosine deaminase than in H. pylori-negative autistic children. Mitochondrial dysfunction, H. pylori infection and low cholesterol were prevalent among autistic male children, which should be targeted during autism management.

Indexed as

MetabolomeAdenosine DeaminaseAntigens, BacterialAutistic DisorderBiomarkersChildChild, PreschoolCholesterolGonadal Steroid HormonesHelicobacter pyloriHumansHydrocortisoneMaleMetals, HeavyMitochondriaOxidative StressAdenosine DeaminaseAntigens, BacterialBiomarkersCholesterolGonadal Steroid HormonesHydrocortisoneMetals, HeavyAbnormal metabolismAutismBiochemical assessmentsCARSIQSSP

Identifiers

PMID30600432
OpenAlexW2904857671

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.