Evidence map›Paper›PMID 30600396›Full record

ReviewCurrent genetics2019

Spatiotemporal regulation of the Dma1-mediated mitotic checkpoint coordinates mitosis with cytokinesis.

Sierra N Cullati, Kathleen L Gould

Open access · greenAbstract readReview
In one paragraph

Review in Current genetics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
0.7field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 15 citations in OpenAlex.

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  6. Characterization of temperature-sensitivemicroPublication biology · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Sierra N CullatiVanderbilt University School of Medicine, Nashville, USA.ORCID https://orcid.org/0000-0001-6477-0459
Kathleen L GouldVanderbilt University School of Medicine, Nashville, USA. kathy.gould@vanderbilt.edu.ORCID http://orcid.org/0000-0002-3810-4070
Vanderbilt University · US

Funding

Integrated Biological Systems Training in OncologyT32CA119925 · NCI · VANDERBILT UNIVERSITY · PI Vivian Gama, William Patrick Tansey · 2008 to 2026
$7.6M
Checkpoint control of cytokinesisR01GM112989 · NIGMS · VANDERBILT UNIVERSITY · PI GOULD, KATHLEEN L · 2014 to 2017
$1.5M
National Institute of General Medical Sciences 112989NCI NIH HHS T32 CA119925NIGMS NIH HHS R01 GM112989
6 · The paper itself

Abstract

During cell division, the timing of mitosis and cytokinesis must be ordered to ensure that each daughter cell receives a complete, undamaged copy of the genome. In fission yeast, the septation initiation network (SIN) is responsible for this coordination, and a mitotic checkpoint dependent on the E3 ubiquitin ligase Dma1 and the protein kinase CK1 controls SIN signaling to delay cytokinesis when there are errors in mitosis. The participation of kinases and ubiquitin ligases in cell cycle checkpoints that maintain genome integrity is conserved from yeast to human, making fission yeast an excellent model system in which to study checkpoint mechanisms. In this review, we highlight recent advances and remaining questions related to checkpoint regulation, which requires the synchronized modulation of protein ubiquitination, phosphorylation, and subcellular localization.

Indexed as

Cell Cycle CheckpointsCytokinesisMitosisSpatio-Temporal AnalysisCell Cycle ProteinsPhosphorylationSchizosaccharomycesSchizosaccharomyces pombe ProteinsUbiquitinationCell Cycle ProteinsDma1 protein, S pombeSchizosaccharomyces pombe ProteinsCell cycle checkpointCell divisionCHFRCK1CytokinesisDma1MitosisSIN

Identifiers

PMID30600396
PMCPMC6511297
OpenAlexW2908049567

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.