ArticleArchives of toxicology2019
Sex-dependent effects of bisphenol A on type 1 diabetes development in non-obese diabetic (NOD) mice.
Article in Archives of toxicology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 2 of them syntheses that pooled it.
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Who cites it
24 citing papers in PubMed, 2 syntheses or guidelines pooled it, 43 citations in OpenAlex.
- Endocrine-Disrupting Chemicals and the Development of Diabetes Mellitus Type 1: A 5-Year Systematic Review.International journal of molecular sciences · 2024Pooled it
- Pooled it
- Vitamin E fails to prevent bisphenol S induced testicular damage in diabetic rats.Scientific reports · 2026Article
- Environmental Mechanisms Influencing the Pathogenesis and Progression of Type 1 Diabetes.International journal of molecular sciences · 2025Review
- Obesity and obesity related disease in adulthood: the dark side of early life exposure to Environmental Chemical Disruptors.Journal of endocrinological investigation · 2025Review
- Inhalation of 2,2',5,5'-tetrachlorobiphenyl (PCB52) causes changes to the gut microbiome throughout the gastrointestinal tract.Journal of hazardous materials · 2024Article
- The potential Association of Bisphenol A exposure and type 1 diabetes mellitus among Dakahlia Governorate's children sample, Egypt.Toxicology research · 2024Article
- An Overview of the Health Effects of Bisphenol A from a One Health Perspective.Animals : an open access journal from MDPI · 2023Review
- A review on immunomodulatory effects of BPA analogues.Archives of toxicology · 2023Review
- Food contaminants and potential risk of diabetes development: A narrative review.World journal of diabetes · 2023Review
- Endocrine disruptors in plastics alter β-cell physiology and increase the risk of diabetes mellitus.American journal of physiology. Endocrinology and metabolism · 2023Review
- Article
- To Waste or Not to Waste: Questioning Potential Health Risks of Micro- and Nanoplastics with a Focus on Their Ingestion and Potential Carcinogenicity.Exposure and health · 2023Review
- Current knowledge on the effects of environmental contaminants in early life nutrition.Frontiers in nutrition · 2023Review
- Behavioral changes and hyperglycemia in NODEF mice following bisphenol S exposure are affected by diets.Neurotoxicology · 2021Article
- Plastics and the microbiome: impacts and solutions.Environmental microbiome · 2021Review
- Interplay Between Endocrine Disruptors and Immunity: Implications for Diseases of Autoreactive Etiology.Frontiers in pharmacology · 2021Review
- Obesogens: How They Are Identified and Molecular Mechanisms Underlying Their Action.Frontiers in endocrinology · 2021Review
- The Impact of Environmental Chemicals on the Gut Microbiome.Toxicological sciences : an official journal of the Society of Toxicology · 2020Article
- The Influence of Bisphenol a on the Nitrergic Nervous Structures in the Domestic Porcine Uterus.International journal of molecular sciences · 2020Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Type 1 diabetes (T1D) is an autoimmune disease caused by immune-mediated pancreatic β-cell destruction. The endocrine disrupting chemical bisphenol A (BPA) has widespread human exposure and can modulate immune function and the gut microbiome (GMB), which may contribute to the increasing T1D incidence worldwide. It was hypothesized that BPA had sex-dependent effects on T1D by modulating immune homeostasis and GMB. Adult female and male non-obese diabetic (NOD) mice were orally administered BPA at environmentally relevant doses (30 or 300 µg/kg). Antibiotic-treated adult NOD females were exposed to 0 or 30 µg/kg BPA. BPA accelerated T1D development in females, but delayed males from T1D. Consistently, females had a shift towards pro-inflammation (e.g., increased macrophages and Bacteroidetes), while males had increases in anti-inflammatory immune factors and a decrease in both anti- and pro-inflammatory GMB. Although bacteria altered during sub-acute BPA exposure differed from bacteria altered from chronic BPA exposure in both sexes, the GMB profile was consistently pro-inflammatory in females, while males had a general decrease of both anti- and pro-inflammatory gut microbes. However, treatment of females with the antibiotic vancomycin failed to prevent BPA-induced glucose intolerance, suggesting changes in Gram-positive bacteria were not a primary mechanism. In conclusion, BPA exposure was found to have sex dimorphic effects on T1D with detrimental effects in females, and immunomodulation was identified as the primary mechanism.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.