Evidence map›Paper›PMID 30600358›Full record

ArticleCellular and molecular life sciences : CMLS2019

Potentiation of a neuronal nicotinic receptor via pseudo-agonist site.

Simone Mazzaferro, Isabel Bermudez, Steven M Sine

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cellular and molecular life sciences : CMLS, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 19 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Review
  6. Concatemers to re-investigate the role of α5 in α4β2 nicotinic receptors.Cellular and molecular life sciences : CMLS · 2021
    Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 2 countries.

Simone MazzaferroReceptor Biology Laboratory, Department of Physiology and Biomedical Engineering, Mayo Clinic College of Medicine, Rochester, MN, 55905, USA.
Isabel BermudezSchool of Life Sciences, Oxford Brookes University, Oxford, OX3 OBP, UK.
Steven M SineReceptor Biology Laboratory, Department of Physiology and Biomedical Engineering, Mayo Clinic College of Medicine, Rochester, MN, 55905, USA. sine@mayo.edu.
Mayo Clinic · USOxford Brookes University · GB

Funding

STRUCTURE/FUNCTION OF THE ACETYLCHOLINE RECEPTORR01NS031744 · NINDS · MAYO CLINIC ROCHESTER · PI SINE, STEVEN M · 1992 to 2023
$7.3M
Structure and Function of the Acetylcholine ReceptorR37NS031744 · NINDS · MAYO CLINIC ROCHESTER · PI SINE, STEVEN M · 2001 to 2007
$4.1M
NIH HHS NS31744NINDS NIH HHS R01 NS031744NINDS NIH HHS R37 NS031744
6 · The paper itself

Abstract

Neuronal nicotinic receptors containing α4 and β2 subunits assemble in two pentameric stoichiometries, (α4)

Indexed as

AcetylcholineAction PotentialsBinding SitesDrug SynergismHEK293 CellsHumansModels, MolecularMutationNeuronsNicotinic AgonistsOxadiazolesProtein ConformationProtein IsoformsProtein SubunitsPyridinesReceptors, Nicotinic3-(3-(pyridine-3-yl)-1,2,4-oxadiazol-5-yl)benzonitrileAcetylcholineNicotinic AgonistsOxadiazolesProtein IsoformsProtein SubunitsPyridinesReceptors, NicotinicLigand-gated ion channelsNeurotransmittersNicotine addictionPAMProtein interfaces

Identifiers

PMID30600358
PMCPMC8022356
OpenAlexW2908103814

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.