ReviewModern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc2019
Limited biopsies of soft tissue tumors: the contemporary role of immunohistochemistry and molecular diagnostics.
Review in Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Diagnosis and Therapy of Soft Tissue Sarcomas: Spanish Group for Research in Sarcomas (GEIS) Guidelines.Cancers · 2025Guideline
- Diagnosis and Management of Soft-Tissue Sarcomas: Current Insights.Journal of the American Academy of Orthopaedic Surgeons. Global research & reviews · 2026Review
- A rare incidence of primary pulmonary undifferentiated pleomorphic sarcoma detected as an endobronchial mass and treated by bronchoscopic resection: a case report and literature review.Frontiers in oncology · 2026Article
- Radiogenomic MRI biomarkers for noninvasive prediction of GPC3 expression and tumor microenvironment in hepatocellular carcinoma.Journal of translational medicine · 2025Article
- Robot-assisted laparoscopic prostate-sparing resection of an extremely rare periprostatic solitary fibrous tumor: a case report and literature review.World journal of surgical oncology · 2025Review
- Case Report: Primary cutaneous apocrine carcinoma mimicking breast carcinoma - a rare diagnostic challenge.Frontiers in oncology · 2025Article
- Lymphoedema - Filariasis or soft tissue sarcoma? A case report.Malaysian family physician : the official journal of the Academy of Family Physicians of Malaysia · 2025Article
- Article
- Left distal sciatic giant solitary myxoid neurofibroma: a case report & literature review.Frontiers in surgery · 2024Article
- FISH Diagnostic Assessment ofInternational journal of molecular sciences · 2023Article
- Primary Leiomyosarcoma of the Mediastinum: A Rare and Challenging Diagnosis?Diagnostics (Basel, Switzerland) · 2022Article
- Primary desmoplastic small round cell tumor of the submandibular gland: a case report and literature review.Diagnostic pathology · 2022Review
- Theranostic cells: emerging clinical applications of synthetic biology.Nature reviews. Genetics · 2021Review
- Cellular solitary fibrous tumor in the mental area: a case report and literature review.The Journal of international medical research · 2021Review
- Intradural Extramedullary Epithelioid Hemangioendothelioma of the Thoracic Spinal Cord: A Case Report.NMC case report journal · 2021Article
- Role of Intraoperative Pathology Consultation by Imprint and Scrape Cytology in Soft Tissue Tumors and Tumor-Like Lesions.Sarcoma · 2021Article
- Histone H3K27 dimethyl loss is highly specific for malignant peripheral nerve sheath tumor and distinguishes true PRC2 loss from isolated H3K27 trimethyl loss.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2019Article
Corrections and comments
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Authors and funding
1 author.
Funding
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Abstract
Diagnosing soft tissue tumors is challenging, even on ample incisional biopsies or resection specimens. There are more than 100 distinct types of soft tissue neoplasms, including more than 80 benign and intermediate mesenchymal tumors and around 40 soft tissue sarcomas. Accurate diagnosis relies first upon recognition of characteristic histologic and cytologic features, including architecture, stromal characteristics, vascular patterns, and dominant cytology; these features may not be represented or apparent in limited core needle biopsy or fine needle aspiration specimens. Once a differential diagnosis is established, application of immunohistochemistry and cytogenetic or molecular diagnostic assays (especially fluorescence in situ hybridization) is used in an attempt to reach a specific diagnosis. In recent years, the diagnostic armamentarium for soft tissue tumors has expanded dramatically, following the discovery of molecular alterations that underlie the pathogenesis of soft tissue tumors. These include new diagnostic immunohistochemical markers that serve as useful surrogates for molecular genetic alterations. Availability of such markers has improved our ability to render accurate and specific diagnoses based on limited biopsy samples. In this review, examples of recently developed markers for the diagnosis of selected soft tissue tumor types will be discussed, including solitary fibrous tumor (STAT6), malignant peripheral nerve sheath tumor (H3K27me3), epithelioid hemangioendothelioma (CAMTA1), dedifferentiated liposarcoma (MDM2), and CIC-DUX4 sarcoma (WT1 and ETV4).
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