Evidence map›Paper›PMID 30600262›Full record

ArticleScience signaling2019

GPR35 promotes glycolysis, proliferation, and oncogenic signaling by engaging with the sodium potassium pump.

Georg Schneditz, Joshua E Elias, Ester Pagano, M Zaeem Cader, Svetlana Saveljeva, Kathleen Long, Subhankar Mukhopadhyay, Maryam Arasteh, Trevor D Lawley, Gordon Dougan and 4 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Science signaling, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers.

0numbers the graph read from it
0cells of the map it votes in
55citing papers in PubMed
3.4field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

55 citing papers in PubMed, 89 citations in OpenAlex.

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  10. Unmet needs in autoimmune liver diseases.Current opinion in immunology · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 3 countries.

Georg SchneditzDivision of Gastroenterology and Hepatology, Department of Medicine, University of Cambridge, Cambridge CB2 0QQ, UK.ORCID 0000-0001-6734-5861
Joshua E EliasDivision of Gastroenterology and Hepatology, Department of Medicine, University of Cambridge, Cambridge CB2 0QQ, UK.ORCID 0000-0003-2137-117X
Ester PaganoDivision of Gastroenterology and Hepatology, Department of Medicine, University of Cambridge, Cambridge CB2 0QQ, UK.
M Zaeem CaderDivision of Gastroenterology and Hepatology, Department of Medicine, University of Cambridge, Cambridge CB2 0QQ, UK.ORCID 0000-0002-4121-748X
Svetlana SaveljevaDivision of Gastroenterology and Hepatology, Department of Medicine, University of Cambridge, Cambridge CB2 0QQ, UK.ORCID 0000-0002-0644-9752
Kathleen LongWellcome Trust Sanger Institute, Hinxton, CB10 1SA, UK.
Subhankar MukhopadhyayWellcome Trust Sanger Institute, Hinxton, CB10 1SA, UK.
Maryam ArastehWellcome Trust Sanger Institute, Hinxton, CB10 1SA, UK.
Trevor D LawleyWellcome Trust Sanger Institute, Hinxton, CB10 1SA, UK.
Gordon DouganWellcome Trust Sanger Institute, Hinxton, CB10 1SA, UK.
Andrew BassettWellcome Trust Sanger Institute, Hinxton, CB10 1SA, UK.ORCID 0000-0003-1632-9137
Tom H KarlsenNorwegian PSC Research Center, Department of Transplantation Medicine and Institute of Clinical Medicine, Oslo University Hospital and University of Oslo, 0027 Oslo, Norway.
Arthur KaserDivision of Gastroenterology and Hepatology, Department of Medicine, University of Cambridge, Cambridge CB2 0QQ, UK.ORCID 0000-0003-1419-3344
Nicole C KaneiderDivision of Gastroenterology and Hepatology, Department of Medicine, University of Cambridge, Cambridge CB2 0QQ, UK. nk428@cam.ac.uk.ORCID 0000-0002-6079-4389
University of Cambridge · GBWellcome Sanger Institute · GBOslo University Hospital · NOKing's College London · GB

Funding

Wellcome TrustWellcome Trust 103077/Z/13/ZWellcome Trust 106260/Z/14/ZWellcome Trust UNS59491
6 · The paper itself

Abstract

The sodium potassium pump (Na/K-ATPase) ensures the electrochemical gradient of a cell through an energy-dependent process that consumes about one-third of regenerated ATP. We report that the G protein-coupled receptor GPR35 interacted with the α chain of Na/K-ATPase and promotes its ion transport and Src signaling activity in a ligand-independent manner. Deletion of Gpr35 increased baseline Ca

Indexed as

Cell ProliferationGlycolysisSignal TransductionAnimalsCarcinogenesisColitis, UlcerativeEpithelial CellsHEK293 CellsHumansIntestinal MucosaMacrophagesMice, KnockoutPolymorphism, Single NucleotideReceptors, G-Protein-CoupledSodium-Potassium-Exchanging ATPasesrc-Family KinasesGPR35 protein, mouseReceptors, G-Protein-CoupledSodium-Potassium-Exchanging ATPasesrc-Family Kinases

Identifiers

PMID30600262
PMCPMC6364804
OpenAlexW2906670900

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.