Evidence map›Paper›PMID 30599092›Full record

ArticleeLife2019

Timing mechanism of sexually dimorphic nervous system differentiation.

Laura Pereira, Florian Aeschimann, Chen Wang, Hannah Lawson, Esther Serrano-Saiz, Douglas S Portman, Helge Großhans, Oliver Hobert

Open access · goldAbstract read
In one paragraph

Article in eLife, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed
3.3field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

43 citing papers in PubMed, 71 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. The PVD neuron has male-specific structure and mating function inProceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  10. Nervous system-wide analysis of allScience advances · 2025
    Article
  11. Article
  12. Article
  13. Review
  14. Genes in Axonal Regeneration.Molecular neurobiology · 2024
    Review
  15. Article
  16. A neurotransmitter atlas ofbioRxiv : the preprint server for biology · 2024
    Article
  17. Review
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Laura PereiraDepartment of Biological Sciences, Howard Hughes Medical Institute, Columbia University, New York, United States.ORCID 0000-0002-8239-3703
Florian AeschimannFriedrich Miescher Institute for Biomedical Research, Basel, Switzerland.ORCID 0000-0001-5213-034X
Chen WangDepartment of Biological Sciences, Howard Hughes Medical Institute, Columbia University, New York, United States.
Hannah LawsonDepartment of Biology, University of Rochester, Rochester, United States.
Esther Serrano-SaizDepartment of Biological Sciences, Howard Hughes Medical Institute, Columbia University, New York, United States.
Douglas S PortmanDepartment of Biology, University of Rochester, Rochester, United States.
Helge GroßhansFriedrich Miescher Institute for Biomedical Research, Basel, Switzerland.ORCID 0000-0002-8169-6905
Oliver HobertDepartment of Biological Sciences, Howard Hughes Medical Institute, Columbia University, New York, United States.ORCID 0000-0002-7634-2854
Howard Hughes Medical Institute · USUniversity of Basel · CHUniversity of Rochester · US

Funding

Sexually dimorphic regulation of neuronal identity in C.elegansR37NS039996 · NINDS · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI HOBERT, OLIVER · 2015 to 2021
$2.5M
Neurogenetic mechanisms of sensory circuit plasticityR01GM130136 · NIGMS · UNIVERSITY OF ROCHESTER · PI PORTMAN, DOUGLAS S · 2018 to 2021
$1.2M
Genetic and Hormonal Mechanisms of Sex Differences in the Nervous SystemR01GM108885 · NIGMS · UNIVERSITY OF ROCHESTER · PI PORTMAN, DOUGLAS S · 2014 to 2017
$1.1M
NIGMS NIH HHS R01 GM108885NIGMS NIH HHS R01 GM130136NIH HHS 2R37NS039996NINDS NIH HHS R37 NS039996Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung 31003A_163447
6 · The paper itself

Abstract

The molecular mechanisms that control the timing of sexual differentiation in the brain are poorly understood. We found that the timing of sexually dimorphic differentiation of postmitotic, sex-shared neurons in the nervous system of the

Indexed as

Amino Acid SequenceAnimalsCaenorhabditis elegansCaenorhabditis elegans ProteinsCell DifferentiationFemaleGene Expression Regulation, DevelopmentalLarvaMaleMicroRNAsNervous SystemNeuronsSequence Homology, Amino AcidSex DifferentiationSex FactorsTime FactorsCaenorhabditis elegans Proteinslet-7 microRNA, C elegansLIN-41 protein, C elegansMicroRNAsTranscription FactorsC. elegansgene regulationgeneticsneurosciencesexual differentiation

Identifiers

PMID30599092
PMCPMC6312707
OpenAlexW2950667797

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.