ArticleInternational journal of applied & basic medical research
Exposure to Enriched Environment Restores Altered Passive Avoidance Learning and Ameliorates Hippocampal Injury in Male Albino Wistar Rats Subjected to Chronic Restraint Stress.
Article in International journal of applied & basic medical research. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed, 8 citations in OpenAlex.
- Does Enriched Environment Improve Chronic Immobilization Stress-Induced Cognitive and Behavioral Changes in Adult Male Rats?Cellular and molecular neurobiology · 2026Article
- Effects of the suppression of 5-HTNaunyn-Schmiedeberg's archives of pharmacology · 2024Article
- Dietary Fructose Intake and Hippocampal Structure and Connectivity during Childhood.Nutrients · 2020Article
- Exposure to Enriched Environment May Act Epigenetically to Correct Defects due to Chronic Restraint Stress in Rats.International journal of applied & basic medical researchArticle
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsThe aim of the study was to investigate the effects of exposure to enriched environment (EE) on passive avoidance learning and hippocampal cellular morphology in rats exposed to chronic restraint stress. MATERIALS AND
methodsAdult male albino Wistar rats were assigned into the following groups: normal control (NC) remained undisturbed in their home cages; stressed group (S) subjected to restrained stress (6 h/day) followed by housing in standard housing for 21 days; And stressed + EE (S + EE) subjected to restrained stress followed by housing in EE for 21 days. On 22 STATISTICAL ANALYSIS USED: Data were analyzed using one-way analysis of variance followed by Tukey's multiple comparison test (
resultsStressed rats exposed to EE showed significant improvement in passive avoidance learning test compared to NC. Quantification of the surviving neurons in the hippocampal subfields and their cellular morphology revealed significant neuroprotection in S + EE in cornu ammonis-2 (CA2) neurons and CA3 hippocampal neurons. No significant changes were found in CA1 hippocampal subfield.
conclusionsThe outcome of this study makes us to think the possibilities of adopting EE as an alternative strategy in brain diseases where there is chronic stress and to minimize the impairment in learning and memory.
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Registered trials
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