ArticleJournal of oral microbiology2019
Xylitol and sorbitol effects on the microbiome of saliva and plaque.
Article in Journal of oral microbiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06370091 (Effect of Xylitol-based Chewing Gums, Sugar-free and Sugared, on Salivary Flow and pH in Young Adults), which is not on this map. Cited by 18 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effect of Xylitol-based Chewing Gums, Sugar-free and Sugared, on Salivary Flow and pH in Young Adults: Randomized Controlled Clinical Trial
Who cites it
18 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Specific effects of xylitol chewing gum on mutans streptococci levels, plaque accumulation and caries occurrence: a systematic review.BMC oral health · 2025Pooled it
- Clinical Effects of Sugar Substitutes on Cariogenic Bacteria: A Systematic Review and Meta-Analysis.International dental journal · 2024Pooled it
- Effect of xylitol on Porphyromonas gingivalis: A systematic review.Clinical and experimental dental research · 2023Pooled it
- Effects of sugar-free polyol chewing gums on gingival inflammation: a systematic review.Clinical oral investigations · 2022Pooled it
- Phosphorylated lantibiotics-producing commensals integrate into the human oral microbiome to suppress pathogens and promote microbiome homeostasis.NPJ biofilms and microbiomes · 2026Article
- Oral hygiene agents at work: effects onFrontiers in cellular and infection microbiology · 2026Review
- L-proline supplementation affects non-volatile flavour perception through oral microbiome metabolic pathways.NPJ science of food · 2025Article
- Biomimetic Effect of Saliva on Human Tooth Enamel: A Scanning Electron Microscopic Study.International journal of dentistry · 2025Article
- Antibacterial Effectiveness and Periodontal Actions of Sugar-Free Chewing Gums Derived From Alcohol or Vegetables in Patients with Fixed Orthodontic Treatment: A Systematic Review.Clinical, cosmetic and investigational dentistry · 2025Review
- Enhanced dominance of nitrate-reducing bacteria using a combination of nitrate and erythritol inJournal of oral microbiology · 2025Article
- Manipulating the diseased oral microbiome: the power of probiotics and prebiotics.Journal of oral microbiology · 2024Review
- The effect of physical and psychological stress on the oral microbiome.Frontiers in psychology · 2023Article
- Xylitol-Containing Chewing Gum Reduces Cariogenic and Periodontopathic Bacteria in Dental Plaque-Microbiome Investigation.Frontiers in nutrition · 2022Article
- Artificial Saliva for Therapeutic Management of Xerostomia: A Narrative Review.Journal of pharmacy & bioallied sciences · 2021Review
- Characteristics of Nutraceutical Chewing Candy Formulations Based on Fermented Milk Permeate, Psyllium Husk, and Apple By-Products.Foods (Basel, Switzerland) · 2021Article
- Article
- Oral Microbiota Display Profound Differential Metabolic Kinetics and Community Shifts upon Incubation with Sucrose, Trehalose, Kojibiose, and Xylitol.Applied and environmental microbiology · 2020Article
- Analysis of oral bacterial communities: comparison of HOMIJournal of oral microbiology · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Chewing gum containing xylitol may help prevent caries by reducing levels of mutans streptococci (MS) and lactobacilli in saliva and plaque. Very little is known about other species which are possibly beneficial to oral health. In this study, we employed high-throughput sequencing of the 16S rRNA gene to profile microbial communities of saliva and plaque following short-term consumption of xylitol and sorbitol containing chewing gum. Participants (
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.