ArticleGenes and environment : the official journal of the Japanese Environmental Mutagen Society2018
Low-dose radiation from A-bombs elongated lifespan and reduced cancer mortality relative to un-irradiated individuals.
Article in Genes and environment : the official journal of the Japanese Environmental Mutagen Society, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- Cellular, Molecular, and Behavioural Sequelae of Early-Life Continuous Low-Dose-Rate Irradiation in Mice.Cells · 2026Article
- Mechanistic Effects of Environmental and Medical Low-Dose Radiation Exposure of the Lung.Biomedicines · 2026Review
- Reevaluating the Paradox: Does Low-Dose Radiation from A-Bombs Affect Lifespan and Cancer Mortality?Journal of biomedical physics & engineering · 2025Article
- Effects of non-initial radiation exposure on solid cancer mortality risk among Hiroshima A-bomb survivors.Frontiers in public health · 2025Article
- Population Studies and Molecular Mechanisms of Human Radioadaptive Capabilities: Is It Time to Rethink Radiation Safety Standards?International journal of molecular sciences · 2024Review
- Article
- Alterations in Gut Microbiota Correlate With Hematological Injuries Induced by Radiation in Beagles.International journal of microbiology · 2024Article
- Radiation-response in primary fibroblasts of long-term survivors of childhood cancer with and without second primary neoplasms: the KiKme study.Molecular medicine (Cambridge, Mass.) · 2022Article
- Review
- Cosmic Rays, CT Scans and Education: Additional Factors that Might Influence Longevity and Mortality in Norway.Journal of biomedical physics & engineering · 2022Article
- Evaluation of risk due to chronic low dose ionizing radiation exposure on the birth prevalence of congenital heart diseases (CHD) among the newborns from high-level natural radiation areas of Kerala coast, India.Genes and environment : the official journal of the Japanese Environmental Mutagen Society · 2022Article
- Phytochemicals: Potential Therapeutic Modulators of Radiation Induced Signaling Pathways.Antioxidants (Basel, Switzerland) · 2021Review
- Ionizing Radiation and Translation Control: A Link to Radiation Hormesis?International journal of molecular sciences · 2020Review
- Temporal Trends in X-Ray Exposure during Coronary Angiography and Percutaneous Coronary Intervention.Journal of interventional cardiology · 2020Review
- The prospective mathematical idea satisfying both radiation hormesis under low radiation doses and linear non-threshold theory under high radiation doses.Genes and environment : the official journal of the Japanese Environmental Mutagen Society · 2020Article
- Black rain in Hiroshima: a critique to the Life Span Study of A-bomb survivors, basis of the linear no-threshold model.Genes and environment : the official journal of the Japanese Environmental Mutagen Society · 2020Article
- Correction to: Low-dose radiation from A-bombs elongated lifespan and reduced cancer mortality relative to un-irradiated individuals.Genes and environment : the official journal of the Japanese Environmental Mutagen Society · 2019Article
- 5 Reasons Why Scoliosis X-Rays Are Not Harmful.Dose-response : a publication of International Hormesis SocietyArticle
- X-ray Hesitancy-Response to Jargin and Sohrabi.Dose-response : a publication of International Hormesis SocietyArticle
- Collaborative Study of Thresholds for Mutagens: Adaptive Responses in the Micronucleus Test and Gene Induction by Mutagenic Treatments.Dose-response : a publication of International Hormesis SocietyArticle
Corrections and comments
- Erratum issued
Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The US National Academy of Sciences (NAS) presented the linear no-threshold hypothesis (LNT) in 1956, which indicates that the lowest doses of ionizing radiation are hazardous in proportion to the dose. This spurious hypothesis was not based on solid data. NAS put forward the BEIR VII report in 2006 as evidence supporting LNT. The study described in the report used data of the Life Span Study (LSS) of A-bomb survivors. Estimation of exposure doses was based on initial radiation (5%) and neglected residual radiation (10%), leading to underestimation of the doses. Residual radiation mainly consisted of fallout that poured down onto the ground along with black rain. The black-rain-affected areas were wide. Not only A-bomb survivors but also not-in-the-city control subjects (NIC) must have been exposed to residual radiation to a greater or lesser degree. Use of NIC as negative controls constitutes a major failure in analyses of LSS. Another failure of LSS is its neglect of radiation adaptive responses which include low-dose stimulation of DNA damage repair, removal of aberrant cells via stimulated apoptosis, and elimination of cancer cells via stimulated anticancer immunity. LSS never incorporates consideration of this possibility. When LSS data of longevity are examined, a clear J-shaped dose-response, a hallmark of radiation hormesis, is apparent. Both A-bomb survivors and NIC showed longer than average lifespans. Average solid cancer death ratios of both A-bomb survivors and NIC were lower than the average for Japanese people, which is consistent with the occurrence of radiation adaptive responses (the bases for radiation hormesis), essentially invalidating the LNT model. Nevertheless, LNT has served as the basis of radiation regulation policy. If it were not for LNT, tremendous human, social, and economic losses would not have occurred in the aftermath of the Fukushima Daiichi nuclear plant accident. For many reasons, LNT must be revised or abolished, with changes based not on policy but on science.
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