Evidence map›Paper›PMID 30598584›Full record

ArticleWorld journal of gastroenterology2018

Five years of fecal microbiota transplantation - an update of the Israeli experience.

Sharon A Greenberg, Ilan Youngster, Nathaniel A Cohen, Dan M Livovsky, Jacob Strahilevitz, Eran Israeli, Ehud Melzer, Kalman Paz, Naomi Fliss-Isakov, Nitsan Maharshak

Open access · hybridAbstract readMulticenter Study
In one paragraph

Article in World journal of gastroenterology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. Beyond Antibiotics: What the Future Holds.Antibiotics (Basel, Switzerland) · 2024
    Review
  5. Article
  6. Review
  7. Review article: the future of microbiome-based therapeutics.Alimentary pharmacology & therapeutics · 2022
    Review
  8. Bezlotoxumab Therapy for RecurrentCrohn's & colitis 360 · 2022
    Article
  9. Article
  10. Updates in Treatment of RecurrentJournal of clinical medicine research · 2019
    Review
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 1 country.

Sharon A GreenbergDepartment of Gastroenterology and Liver Diseases, Tel Aviv Sourasky Medical Center, affiliated with the Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 6423906, Israel.
Ilan YoungsterAssaf Harofe Medical Center, Zerifin 70300, Israel.
Nathaniel A CohenDepartment of Gastroenterology and Liver Diseases, Tel Aviv Sourasky Medical Center, affiliated with the Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 6423906, Israel.
Dan M LivovskyDigestive Diseases Institute, Shaare Zedek Medical Center, Jerusalem 91031, Israel.
Jacob StrahilevitzDepartment of Clinical Microbiology and Infectious Diseases, Hadassah-Hebrew University, Jerusalem 91120, Israel.
Eran IsraeliDepartment of Gastroenterology and Liver Diseases, Hadassah-Hebrew University, Jerusalem 91120, Israel.
Ehud MelzerGastrointestinal and Liver Diseases Institute, Kaplan Medical Center, Rehovot 76100, Israel.
Kalman PazDigestive Diseases Institute, Shaare Zedek Medical Center, Jerusalem 91031, Israel.
Naomi Fliss-IsakovDepartment of Gastroenterology and Liver Diseases, Tel Aviv Sourasky Medical Center, affiliated with the Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 6423906, Israel.
Nitsan MaharshakDepartment of Gastroenterology and Liver Diseases, Tel Aviv Sourasky Medical Center, affiliated with the Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 6423906, Israel.
Hebrew University of Jerusalem · ILShaare Zedek Medical Center · ILTel Aviv University · ILKaplan Medical Center · ILTel Aviv Sourasky Medical Center · IL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimTo evaluate and describe the efficacy of fecal microbiota transplantation (FMT) for

methodsAll patients who received FMT for recurrent (recurrence within 8 wk of the previous treatment) or refractory CDI from 2013 through 2017 in all the five medical centers in Israel currently performing FMT were included. Stool donors were screened according to the Israeli Ministry of Health guidelines. Clinical and laboratory data of patients were collected from patients' medical files, and they included indications for FMT, risk factors for CDI and disease severity. Primary outcome was FMT success (at least 2 mo free of CDI-related diarrhea post-FMT). Secondary outcomes included initial response to FMT (cessation of diarrhea within 7 d) and recurrence at 6 mo.

resultsThere were 111 FMTs for CDI, with a median age of 70 years [interquartile range (IQR): 53-82], and 42% (47) males. Fifty patients (45%) were treated

conclusionFMT is a safe and effective treatment for CDI, with capsules emerging as a successful and well-tolerated route. Severe CDI is less likely to respond to FMT.

Indexed as

AgedAged, 80 and overCapsulesClostridioides difficileClostridium InfectionsDiarrheaFecal Microbiota TransplantationFemaleHumansIsraelMaleMiddle AgedRecurrenceRetrospective StudiesSeverity of Illness IndexTreatment OutcomeCapsulesCapsulesClostridium difficile infectionFecal microbiota transplantationIsrael

Identifiers

PMID30598584
PMCPMC6305536
OpenAlexW2906267958

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.