Evidence map›Paper›PMID 30598543›Full record

ArticleNature chemical biology2019

Noncanonical CTD kinases regulate RNA polymerase II in a gene-class-specific manner.

Corey M Nemec, Amit K Singh, Asfa Ali, Sandra C Tseng, Kirtimaan Syal, Kennedy J Ringelberg, Yi-Hsuan Ho, Corinna Hintermair, Mohammad Faiz Ahmad, Rajesh Kumar Kar and 4 more

Open access · greenAbstract read
In one paragraph

Article in Nature chemical biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
1.3field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 41 citations in OpenAlex.

  1. Review
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  6. ThrScience advances · 2024
    Article
  7. Article
  8. Review
  9. Article
  10. Cyclin-dependent kinases: Masters of the eukaryotic universe.Wiley interdisciplinary reviews. RNA · 2023
    Review
  11. Review
  12. Deubiquitinase OTUD3: a double-edged sword in immunity and disease.Frontiers in cell and developmental biology · 2023
    Review
  13. Article
  14. Review
  15. Article
  16. Review
  17. Review
  18. Review
  19. Article
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 3 countries.

Corey M NemecDepartment of Biochemistry, University of Wisconsin-Madison, Madison, WI, USA.ORCID http://orcid.org/0000-0002-6566-1753
Amit K SinghMolecular and Structural Biology Division, CSIR-Central Drug Research Institute, Sector 10, Jankipuram Extension, Lucknow, India.
Asfa AliDepartment of Biochemistry, University of Wisconsin-Madison, Madison, WI, USA.
Sandra C TsengDepartment of Biochemistry, University of Wisconsin-Madison, Madison, WI, USA.
Kirtimaan SyalDepartment of Biochemistry, University of Wisconsin-Madison, Madison, WI, USA.
Kennedy J RingelbergDepartment of Biochemistry, University of Wisconsin-Madison, Madison, WI, USA.
Yi-Hsuan HoLaboratory of Genetics, University of Wisconsin-Madison, Madison, WI, USA.
Corinna HintermairDepartment of Molecular Epigenetics, Helmholtz Center Munich, Center of Integrated Protein Science, Munich, Germany.
Mohammad Faiz AhmadDepartment of Biochemistry, University of Wisconsin-Madison, Madison, WI, USA.
Rajesh Kumar KarDepartment of Biochemistry, University of Wisconsin-Madison, Madison, WI, USA.
Audrey P GaschLaboratory of Genetics, University of Wisconsin-Madison, Madison, WI, USA.
Md Sohail AkhtarMolecular and Structural Biology Division, CSIR-Central Drug Research Institute, Sector 10, Jankipuram Extension, Lucknow, India.
Dirk EickDepartment of Molecular Epigenetics, Helmholtz Center Munich, Center of Integrated Protein Science, Munich, Germany.
Aseem Z AnsariDepartment of Biochemistry, University of Wisconsin-Madison, Madison, WI, USA. azansari@wisc.edu.ORCID http://orcid.org/0000-0003-1432-4498
University of Wisconsin–Madison · USCenter for Integrated Protein Science Munich · DECentral Drug Research Institute · IN

Funding

Functional Genomics of Stress Defense in YeastR01GM083989 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI GASCH, AUDREY · 2008 to 2016
$3.0M
Deciphering the molecular and physiological cues that guide CTD patterning by Bur1/Cdk9R01GM117362 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI ANSARI, ASEEM Z · 2016 to 2019
$1.3M
NIGMS NIH HHS R01 GM083989NIGMS NIH HHS R01 GM117362
6 · The paper itself

Abstract

Phosphorylation of the carboxyl-terminal domain (CTD) of the largest subunit of RNA polymerase II (Pol II) governs stage-specific interactions with different cellular machines. The CTD consists of Y

Indexed as

Amino Acid SequenceCasein Kinase IPhosphorylationPhylogenyProtein DomainsProtein KinasesProtein Serine-Threonine KinasesRNA Polymerase IISaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsThreonineTranscription, Geneticcarboxy-terminal domain kinaseCasein Kinase IHRR25 protein, S cerevisiaeProtein KinasesProtein Serine-Threonine KinasesRNA Polymerase IISaccharomyces cerevisiae ProteinsThreonine

Identifiers

PMID30598543
PMCPMC6339578
OpenAlexW2904327845

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.