ATP-Gated P2X7 Receptors Require Chloride Channels To Promote Inflammation in Human Macrophages.

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

Who cites it

26 citing papers in PubMed, 41 citations in OpenAlex.

1. Immunometabolic regulation and tissue-resident immunity in autoimmune uveitis: from genetic susceptibility to the gut-spleen-eye axis.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2026
   Review
2. Baohuoside I CombatedAntioxidants (Basel, Switzerland) · 2026
   Article
3. P2X7 receptor-dependent microglia-astrocyte coupling in Alzheimer's disease: from eATP sensing to synaptic and proteostatic failure.Frontiers in aging neuroscience · 2026
   Review
4. The eATP/P2×7R Axis Drives Quantum Dot-Nanoparticle Induced Neutrophil Recruitment in the Pulmonary Microcirculation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024
   Article
5. Modulation of Microglial Function by ATP-Gated P2X7 Receptors: Studies in Rat, Mice and Human.Cells · 2024
   Review
6. Moderate physical exercise and ATP modulate the P2X7 receptor and improve cisplatin-induced gastric emptying delay in rats.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2024
   Article
7. Dynamical changes in the expression of GABAergic and purinergic components occur during the polarization of THP-1 monocytes to proinflammatory macrophages.Biochemistry and biophysics reports · 2023
   Article
8. Synthesis and biological evaluation of carboxamide and quinoline derivatives as P2X7R antagonists.Bioorganic chemistry · 2023
   Article
9. Untangling Macropore Formation and Current Facilitation in P2X7.International journal of molecular sciences · 2023
   Review
10. Targeting purinergic receptors to attenuate inflammation of dry eye.Purinergic signalling · 2023
    Review
11. Improved ANAP incorporation and VCF analysis reveal details of P2X7 current facilitation and a limited conformational interplay between ATP binding and the intracellular ballast domain.eLife · 2023
    Article
12. TRPA1 Role in Inflammatory Disorders: What Is Known So Far?International journal of molecular sciences · 2022
    Review
13. Using Whole-Cell Electrophysiology and Patch-Clamp Photometry to Characterize P2X7 Receptor Currents.Methods in molecular biology (Clifton, N.J.) · 2022
    Article
14. Using Symmetrical Organic Cation Solutions to Study P2X7 Ion Permeation.Methods in molecular biology (Clifton, N.J.) · 2022
    Article
15. Inherent P2X7 Receptors Regulate Macrophage Functions during Inflammatory Diseases.International journal of molecular sciences · 2021
    Review
16. P2X7 Receptors and TMEM16 Channels Are Functionally Coupled with Implications for Macropore Formation and Current Facilitation.International journal of molecular sciences · 2021
    Article
17. Hyperactivation of P2X7 receptors as a culprit of COVID-19 neuropathology.Molecular psychiatry · 2021
    Review
18. Update of P2X receptor properties and their pharmacology: IUPHAR Review 30.British journal of pharmacology · 2021
    Review
19. Purinergic Signaling in Endometriosis-Associated Pain.International journal of molecular sciences · 2020
    Review
20. Dissection of P2X4 and P2X7 Receptor Current Components in BV-2 Microglia.International journal of molecular sciences · 2020
    Article

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

Authors and funding

3 authors at 1 institution in 1 country.

Funding

Abstract

Indexed as