Evidence map›Paper›PMID 30598508›Full record

ArticleDrug metabolism and disposition: the biological fate of chemicals2019

Commensal Gut Bacteria Convert the Immunosuppressant Tacrolimus to Less Potent Metabolites.

Yukuang Guo, Camila Manoel Crnkovic, Kyoung-Jae Won, Xiaotong Yang, John Richard Lee, Jimmy Orjala, Hyunwoo Lee, Hyunyoung Jeong

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Drug metabolism and disposition: the biological fate of chemicals, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 72 papers.

0numbers the graph read from it
0cells of the map it votes in
72citing papers in PubMed
7.8field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

72 citing papers in PubMed, 138 citations in OpenAlex.

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  3. Pharmacomicrobiomics-driven targeted drug delivery for precision microbiome modulation.Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences · 2026
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12 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Yukuang GuoDepartments of Medicinal Chemistry and Pharmacognosy (Y.G., C.M.C., J.O., H.L.), Pharmacy Practice (K.-J.W., H.J.), Biopharmaceutical Sciences (X.Y., H.J.), and Center for Biomolecular Sciences (Y.G., J.O., H.L., H.J.), University of Illinois at Chicago, Chicago, Illinois; and Division of Nephrology and Hypertension, Department of Medicine, Weill Cornell Medicine, New York, New York (J.R.L.).
Camila Manoel CrnkovicDepartments of Medicinal Chemistry and Pharmacognosy (Y.G., C.M.C., J.O., H.L.), Pharmacy Practice (K.-J.W., H.J.), Biopharmaceutical Sciences (X.Y., H.J.), and Center for Biomolecular Sciences (Y.G., J.O., H.L., H.J.), University of Illinois at Chicago, Chicago, Illinois; and Division of Nephrology and Hypertension, Department of Medicine, Weill Cornell Medicine, New York, New York (J.R.L.).
Kyoung-Jae WonDepartments of Medicinal Chemistry and Pharmacognosy (Y.G., C.M.C., J.O., H.L.), Pharmacy Practice (K.-J.W., H.J.), Biopharmaceutical Sciences (X.Y., H.J.), and Center for Biomolecular Sciences (Y.G., J.O., H.L., H.J.), University of Illinois at Chicago, Chicago, Illinois; and Division of Nephrology and Hypertension, Department of Medicine, Weill Cornell Medicine, New York, New York (J.R.L.).
Xiaotong YangDepartments of Medicinal Chemistry and Pharmacognosy (Y.G., C.M.C., J.O., H.L.), Pharmacy Practice (K.-J.W., H.J.), Biopharmaceutical Sciences (X.Y., H.J.), and Center for Biomolecular Sciences (Y.G., J.O., H.L., H.J.), University of Illinois at Chicago, Chicago, Illinois; and Division of Nephrology and Hypertension, Department of Medicine, Weill Cornell Medicine, New York, New York (J.R.L.).
John Richard LeeDepartments of Medicinal Chemistry and Pharmacognosy (Y.G., C.M.C., J.O., H.L.), Pharmacy Practice (K.-J.W., H.J.), Biopharmaceutical Sciences (X.Y., H.J.), and Center for Biomolecular Sciences (Y.G., J.O., H.L., H.J.), University of Illinois at Chicago, Chicago, Illinois; and Division of Nephrology and Hypertension, Department of Medicine, Weill Cornell Medicine, New York, New York (J.R.L.).
Jimmy OrjalaDepartments of Medicinal Chemistry and Pharmacognosy (Y.G., C.M.C., J.O., H.L.), Pharmacy Practice (K.-J.W., H.J.), Biopharmaceutical Sciences (X.Y., H.J.), and Center for Biomolecular Sciences (Y.G., J.O., H.L., H.J.), University of Illinois at Chicago, Chicago, Illinois; and Division of Nephrology and Hypertension, Department of Medicine, Weill Cornell Medicine, New York, New York (J.R.L.) orjala@uic.edu hlee31@uic.edu yjeong@uic.edu.
Hyunwoo LeeDepartments of Medicinal Chemistry and Pharmacognosy (Y.G., C.M.C., J.O., H.L.), Pharmacy Practice (K.-J.W., H.J.), Biopharmaceutical Sciences (X.Y., H.J.), and Center for Biomolecular Sciences (Y.G., J.O., H.L., H.J.), University of Illinois at Chicago, Chicago, Illinois; and Division of Nephrology and Hypertension, Department of Medicine, Weill Cornell Medicine, New York, New York (J.R.L.) orjala@uic.edu hlee31@uic.edu yjeong@uic.edu.
Hyunyoung JeongDepartments of Medicinal Chemistry and Pharmacognosy (Y.G., C.M.C., J.O., H.L.), Pharmacy Practice (K.-J.W., H.J.), Biopharmaceutical Sciences (X.Y., H.J.), and Center for Biomolecular Sciences (Y.G., J.O., H.L., H.J.), University of Illinois at Chicago, Chicago, Illinois; and Division of Nephrology and Hypertension, Department of Medicine, Weill Cornell Medicine, New York, New York (J.R.L.) orjala@uic.edu hlee31@uic.edu yjeong@uic.edu.
Cornell University · USUniversity of Illinois Chicago · USWeill Cornell Medicine · US

Funding

Gut Microbiome, Acute Rejection, and Tacrolimus Dosing in Kidney TransplantationK23AI124464 · NIAID · WEILL MEDICAL COLL OF CORNELL UNIV · PI LEE, JOHN RICHARD · 2016 to 2020
$944k
NIAID NIH HHS K23 AI124464
6 · The paper itself

Abstract

Tacrolimus exhibits low and variable drug exposure after oral dosing, but the contributing factors remain unclear. Based on our recent report showing a positive correlation between fecal abundance of

Indexed as

Administration, OralAdultAgedCells, CulturedDose-Response Relationship, DrugFaecalibacterium prausnitziiFecesFemaleGastrointestinal MicrobiomeGraft RejectionHealthy VolunteersHumansImmunosuppression TherapyImmunosuppressive AgentsKidney TransplantationLeukocytes, MononuclearImmunosuppressive AgentsTacrolimus

Identifiers

PMID30598508
PMCPMC6367689
OpenAlexW2951407024

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.