Evidence map›Paper›PMID 30598475›Full record

ArticleJournal of lipid research2019

An upstream enhancer regulates

Christopher M Allan, Patrick J Heizer, Yiping Tu, Norma P Sandoval, Rachel S Jung, Jazmin E Morales, Eniko Sajti, Ty D Troutman, Thomas L Saunders, Darren A Cusanovich and 4 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of lipid research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.7field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. A protein of capillary endothelial cells, GPIHBP1, is crucial for plasma triglyceride metabolism.Proceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  2. Article
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 5 institutions in 1 country.

Christopher M AllanDepartments of Medicine University of California, Los Angeles, Los Angeles, CA 90095.
Patrick J HeizerDepartments of Medicine University of California, Los Angeles, Los Angeles, CA 90095.
Yiping TuDepartments of Medicine University of California, Los Angeles, Los Angeles, CA 90095.
Norma P SandovalDepartments of Medicine University of California, Los Angeles, Los Angeles, CA 90095.
Rachel S JungDepartments of Medicine University of California, Los Angeles, Los Angeles, CA 90095.
Jazmin E MoralesDepartments of Medicine University of California, Los Angeles, Los Angeles, CA 90095.
Eniko SajtiDepartment of Pediatrics, Division of Neurology, Rady Children's Hospital, University of California, San Diego, San Diego, CA 92123.
Ty D TroutmanDepartment of Cellular and Molecular Medicine, School of Medicine, University of California, San Diego, La Jolla, CA 92093.
Thomas L SaundersUniversity of Michigan Transgenic Animal Model Core, Department of Medicine, University of Michigan Medical School, Ann Arbor, MI 48109.
Darren A CusanovichDepartment of Cellular and Molecular Medicine, University of Arizona, Tucson, AZ 85721.
Anne P BeigneuxDepartments of Medicine University of California, Los Angeles, Los Angeles, CA 90095.
Casey E RomanoskiDepartment of Cellular and Molecular Medicine, University of Arizona, Tucson, AZ 85721. Electronic address: cromanoski@email.arizona.edu.
Loren G FongDepartments of Medicine University of California, Los Angeles, Los Angeles, CA 90095. Electronic address: lfong@mednet.ucla.edu.
Stephen G YoungDepartments of Medicine University of California, Los Angeles, Los Angeles, CA 90095; Human Genetics, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095. Electronic address: sgyoung@mednet.ucla.edu.
University of California, Los Angeles · USUniversity of Arizona · USRady Children's Hospital-San Diego · USUniversity of California, San Diego · USUniversity of Michigan–Ann Arbor · US

Funding

VirologyP30AI036214 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SONIA JAIN · 1994 to 2026
$78.4M
SOUTHWEST ENVIRONMENTAL HEALTH SCIENCES CENTERP30ES006694 · NIEHS · UNIVERSITY OF ARIZONA · PI DEAN BILLHEIMER · 1994 to 2026
$36.7M
The Lipin Protein Family and Triglyceride Metabolism P01HL090553 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI YOUNG, STEPHEN G. · 2008 to 2018
$23.3M
Contemporary Approaches to Cancer Cell Signaling and CommunicationT32CA009523 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI DONOGHUE, DANIEL J, YANG, JING · 1985 to 2025
$12.1M
Understanding the Influence of Lipid Homeostasis on T cell FunctionP01HL146358 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI FONG, LOREN GI · 2019 to 2023
$11.7M
CARDIOVASCULAR SCIENTIST TRAINING PROGRAMT32HL007895 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SHIVKUMAR, KALYANAM, WATSON, KAROL E · 1998 to 2023
$9.2M
Refining Physiologic Mechanisms for Intravascular Triglyceride MetabolismR01HL087228 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI BEIGNEUX, ANNE, FONG, LOREN GI · 2007 to 2024
$7.8M
Investigating Mechanisms for Lipid Transport in Health and DiseaseR35HL139725 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI YOUNG, STEPHEN G. · 2018 to 2024
$6.1M
Defining mechanisms for lipid transport across capillary endothelial cellsR01HL125335 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI YOUNG, STEPHEN G. · 2015 to 2017
$1.2M
Regulation of Receptor Tyrosine KinasesR01GM065490 · NIGMS · UNIVERSITY OF CALIFORNIA SAN DIEGO · PI DONOGHUE, DANIEL J · 2002 to 2005
$1.0M
Epigenomics of mononuclear phagocytes in prematurity associated lung diseaseK08HL140198 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SAJTI, ENIKO · 2018 to 2022
$886k
Systems Genetic Analysis of Atherogenic Transcriptional Regulation in Human CellsR00HL123485 · NHLBI · UNIVERSITY OF ARIZONA · PI ROMANOSKI, CASEY E · 2016 to 2018
$740k
NCI NIH HHS T32 CA009523NHLBI NIH HHS K08 HL140198NHLBI NIH HHS K99 HL123485NHLBI NIH HHS P01 HL090553NHLBI NIH HHS P01 HL146358NHLBI NIH HHS R00 HL123485NHLBI NIH HHS R01 HL087228NHLBI NIH HHS R01 HL125335NHLBI NIH HHS R35 HL139725NHLBI NIH HHS T32 HL007895NIAID NIH HHS P30 AI036214NIEHS NIH HHS P30 ES006694NIGMS NIH HHS R01 GM065490
6 · The paper itself

Abstract

Glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1 (GPIHBP1), the protein that shuttles LPL to the capillary lumen, is essential for plasma triglyceride metabolism. When GPIHBP1 is absent, LPL remains stranded within the interstitial spaces and plasma triglyceride hydrolysis is impaired, resulting in severe hypertriglyceridemia. While the functions of GPIHBP1 in intravascular lipolysis are reasonably well understood, no one has yet identified DNA sequences regulating GPIHBP1 expression. In the current studies, we identified an enhancer element located ∼3.6 kb upstream from exon 1 of mouse

Indexed as

Adipose Tissue, BrownAnimalsChromatinCRISPR-Cas SystemsHeartHumansLipoprotein LipaseMiceMice, Inbred StrainsReceptors, LipoproteinSequence Analysis, DNATriglyceridesChromatinGPIHBP1 protein, humanGPI-HBP1 protein, mouseLipoprotein LipaseReceptors, LipoproteinTriglycerideschylomicronsendothelial cellsfatty acid metabolismglycosylphosphatidylinositol-anchored high density lipoprotein–binding protein 1lipidslipolysistriglycerides

Identifiers

PMID30598475
PMCPMC6446700
OpenAlexW2907745712

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.