ArticlePsychiatry research. Neuroimaging2019
Insula thickness asymmetry relates to risk of major depressive disorder in middle-aged to older adults.
Article in Psychiatry research. Neuroimaging, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 3 syntheses or guidelines pooled it, 16 citations in OpenAlex.
- Structural and functional brain alterations in subthreshold depression: A multimodal coordinate-based meta-analysis.Human brain mapping · 2024Pooled it
- Brain morphology changes after spinal cord injury: A voxel-based meta-analysis.Frontiers in neurology · 2022Pooled it
- Insula activity in resting-state differentiates bipolar from unipolar depression: a systematic review and meta-analysis.Scientific reports · 2021Pooled it
- The effects of alcohol use severity and polygenic risk on gray matter volumes in young adults.medRxiv : the preprint server for health sciences · 2025Article
- The effects of alcohol use severity and polygenic risk on gray matter volumes in young adults.Frontiers in psychiatry · 2025Article
- Brain multi-contrast, multi-atlas segmentation of diffusion tensor imaging and ensemble learning automatically diagnose late-life depression.Scientific reports · 2023Article
- Abnormal degree centrality values as a potential imaging biomarker for major depressive disorder: A resting-state functional magnetic resonance imaging study and support vector machine analysis.Frontiers in psychiatry · 2022Article
- Age-dependent brain morphometry in Major Depressive disorder.NeuroImage. Clinical · 2022Article
- A lateralized model of the pain-depression dyad.Neuroscience and biobehavioral reviews · 2021Review
- Differential neural processing of unpleasant sensory stimulation in patients with major depression.European archives of psychiatry and clinical neuroscience · 2021Article
- Impact of sex and depressed mood on the central regulation of cardiac autonomic function.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
A growing body of research implicates the insula as a critical brain structure in major depressive disorder (MDD), emotional salience, and interoception. Despite a high prevalence of depressive symptoms among middle-aged to older adults and the elevated risks that they confer towards poor outcomes like deteriorating health and suicidality, only limited research has examined the role of the insula in this population. The present study investigates associations between insula thickness and risk of developing MDD in middle-aged to older adults. A composite measure of MDD risk was quantified based upon current Beck Depression Inventory-II scores, current antidepressant medication use, and self-reported history of depression. Linear regressions were performed to analyze the relationships between insula thickness and MDD risk. Linear regression established that left-right insula thickness difference and left insula thickness significantly predicted MDD risk; however, right insula thickness did not. These findings provide evidence of the importance of insula thickness in middle-aged to older adults at elevated risk for MDD, while highlighting the left insula as an area of particular interest.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.