ArticleBMC systems biology2018
FMSM: a novel computational model for predicting potential miRNA biomarkers for various human diseases.
Article in BMC systems biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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4 citing papers in PubMed, 11 citations in OpenAlex.
- GBDR: a Bayesian model for precise prediction of pathogenic microorganisms using 16S rRNA gene sequences.BMC genomics · 2022Article
- Experimental validation of a predicted microRNA within humanMolecular biology research communications · 2021Article
- Predicting lncRNA-miRNA InteractionFrontiers in genetics · 2019Article
- A Novel Approach Based on Bipartite Network Recommendation and KATZ Model to Predict Potential Micro-Disease Associations.Frontiers in genetics · 2019Article
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Authors and funding
6 authors at 4 institutions in 2 countries.
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Abstract
backgroundMicroRNA (miRNA) plays a key role in regulation mechanism of human biological processes, including the development of disease and disorder. It is necessary to identify potential miRNA biomarkers for various human diseases. Computational prediction model is expected to accelerate the process of identification.
resultsConsidering the limitations of previously proposed models, we present a novel computational model called FMSM. It infers latent miRNA biomarkers involved in the mechanism of various diseases based on the known miRNA-disease association network, miRNA expression similarity, disease semantic similarity and Gaussian interaction profile kernel similarity. FMSM achieves reliable prediction performance in 5-fold and leave-one-out cross validations with area under ROC curve (AUC) values of 0.9629+/- 0.0127 and 0.9433, respectively, which outperforms the state-of-the-art competitors and classical algorithms. In addition, 19 of top 25 predicted miRNAs have been validated to have associations with Colonic Neoplasms in case study.
conclusionsA factored miRNA similarity based model and miRNA expression similarity substantially contribute to the well-performing prediction. The list of the predicted most latent miRNA biomarkers of various human diseases is publicized. It is anticipated that FMSM could serve as a useful tool guiding the future experimental validation for those promising miRNA biomarker candidates.
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