Evidence map›Paper›PMID 30598082›Full record

ArticleBMC medical genetics2018

Parkinson's disease and Alzheimer's disease: a Mendelian randomization study.

Zhifa Han, Rui Tian, Peng Ren, Wenyang Zhou, Pingping Wang, Meng Luo, Shuilin Jin, Qinghua Jiang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC medical genetics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 1 pooled it
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 1 synthesis or guideline pooled it, 48 citations in OpenAlex.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Zhifa HanSchool of Life Science and Technology, Harbin Institute of Technology, Harbin, China.
Rui TianSchool of Life Science and Technology, Harbin Institute of Technology, Harbin, China.
Peng RenSchool of Life Science and Technology, Harbin Institute of Technology, Harbin, China.
Wenyang ZhouSchool of Life Science and Technology, Harbin Institute of Technology, Harbin, China.
Pingping WangSchool of Life Science and Technology, Harbin Institute of Technology, Harbin, China.
Meng LuoSchool of Life Science and Technology, Harbin Institute of Technology, Harbin, China.
Shuilin JinDepartment of Mathematics, Harbin Institute of Technology, Harbin, China. jinsl@hit.edu.cn.
Qinghua JiangSchool of Life Science and Technology, Harbin Institute of Technology, Harbin, China. qhjiang@hit.edu.cn.
Harbin Institute of Technology · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAlzheimer's disease (AD) and Parkinson's disease (PD) are the top two common neurodegenerative diseases in elderly. Recent studies found the α-synuclein have a key role in AD. Although many clinical and pathological features between AD and PD are shared, the genetic association between them remains unclear, especially whether α-synuclein in PD genetically alters AD risk.

resultsWe did not obtain any significant result (OR = 0.918, 95% CI: 0.782-1.076, P = 0.291) in MR analysis between PD and AD risk. In MR between α-synuclein in PD with AD risk, we only extracted rs356182 as the IV through a strict screening process. The result indicated a significant association based on IVW method (OR = 0.638, 95% CI: 0.485-0.838, P = 1.20E-03). In order to examine the robustness of the IVW method, we used other three complementary analytical methods and also obtained consistent results.

conclusionThe overall PD genetic risk factors did not predict AD risk, but the α-synuclein susceptibility genetic variants in PD reduce the AD risk. We believe that our findings may help to understand the association between them, which may be useful for future genetic studies for both diseases.

Indexed as

Polymorphism, Single NucleotideAgedAllelesalpha-SynucleinAlzheimer DiseaseFemaleGene ExpressionGene FrequencyGenome-Wide Association StudyHumansMaleMendelian Randomization AnalysisNerve Tissue ProteinsOdds RatioParkinson DiseaseRisk Factorsalpha-SynucleinNerve Tissue ProteinsSNCA protein, humanAlzheimer’s diseaseGenetic associationMendelian randomizationParkinson’s diseaseα-synuclein

Identifiers

PMID30598082
PMCPMC6311900
OpenAlexW2907867049

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.