Evidence map›Paper›PMID 30598030›Full record

ArticleBiosensors2018

Real Time Monitoring of a UV Light-Assisted Biofunctionalization Protocol Using a Nanophotonic Biosensor.

Jad Sabek, Luis Torrijos-Morán, Amadeu Griol, Zeneida Díaz Betancor, María-José Bañuls Polo, Ángel Maquieira, Jaime García-Rupérez

Open access · goldAbstract read
In one paragraph

Article in Biosensors, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Jad SabekNanophotonics Technology Center, Universitat Politècnica de València, Camí de Vera s/n, 46022 Valencia, Spain. jasa@ntc.upv.es.
Luis Torrijos-MoránNanophotonics Technology Center, Universitat Politècnica de València, Camí de Vera s/n, 46022 Valencia, Spain. Luitorm2@ntc.upv.es.ORCID 0000-0001-9596-1661
Amadeu GriolNanophotonics Technology Center, Universitat Politècnica de València, Camí de Vera s/n, 46022 Valencia, Spain. agriol@upvnet.upv.es.
Zeneida Díaz BetancorDepartamento de Química, Instituto Interuniversitario de Investigación de Reconocimiento Molecular y Desarrollo Tecnológico IDM, Universitat Politècnica de València, Camí de Vera s/n, 46022 Valencia, Spain. zediabe@upvnet.upv.es.
María-José Bañuls PoloDepartamento de Química, Instituto Interuniversitario de Investigación de Reconocimiento Molecular y Desarrollo Tecnológico IDM, Universitat Politècnica de València, Camí de Vera s/n, 46022 Valencia, Spain. mbpolo@upvnet.upv.es.ORCID 0000-0002-2422-7731
Ángel MaquieiraDepartamento de Química, Instituto Interuniversitario de Investigación de Reconocimiento Molecular y Desarrollo Tecnológico IDM, Universitat Politècnica de València, Camí de Vera s/n, 46022 Valencia, Spain. amaquieira@qim.upv.es.ORCID 0000-0003-4641-4957
Jaime García-RupérezNanophotonics Technology Center, Universitat Politècnica de València, Camí de Vera s/n, 46022 Valencia, Spain. jaigarru@upvnet.upv.es.ORCID 0000-0002-2036-0084
Universitat Politècnica de València · ES

Funding

Horizon 2020 Framework Programme H2020-PHC-634013
6 · The paper itself

Abstract

A protocol for the covalent biofunctionalization of silicon-based biosensors using a UV light-induced thiol⁻ene coupling (TEC) reaction has been developed. This biofunctionalization approach has been used to immobilize half antibodies (hIgG), which have been obtained by means of a tris(2-carboxyethyl)phosphine (TCEP) reduction at the hinge region, to the surface of a vinyl-activated silicon-on-insulator (SOI) nanophotonic sensing chip. The response of the sensing structures within the nanophotonic chip was monitored in real time during the biofunctionalization process, which has allowed us to confirm that the bioconjugation of the thiol-terminated bioreceptors onto the vinyl-activated sensing surface is only initiated upon UV light photocatalysis.

Indexed as

Biosensing TechniquesNanotechnologyUltraviolet RaysNanoparticlesSiliconTime FactorsSiliconbiofunctionalizationhalf antibodiesnanophotonic sensorsilicon on insulatorUV light photocatalysis

Identifiers

PMID30598030
PMCPMC6468802
OpenAlexW2908432249

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.