ArticleMolecules (Basel, Switzerland)2018
Design and Synthesis of C-19 Isosteviol Derivatives as Potent and Highly Selective Antiproliferative Agents.
Article in Molecules (Basel, Switzerland), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 17 citations in OpenAlex.
- Synthesis and Biological Evaluation of Novel C-28 Chloroacetamide-Modified Ursolic Acid Derivatives as Antibacterial Agents.Microorganisms · 2026Article
- Synthesis and Evaluation of Isosteviol Derivatives: Promising Anticancer Therapies for Colon Cancer.Biomedicines · 2025Article
- Enhanced efficacy of brucine dissolving-microneedles as a targeted delivery system in rheumatoid arthritis treatment: a comprehensive pharmacokinetic-pharmacodynamic analysis.Drug delivery and translational research · 2025Article
- Synthesis and Study of the Structure-Activity Relationship of AntiproliferativePharmaceuticals (Basel, Switzerland) · 2024Article
- Boldine promotes stemness of human urine-derived stem cells by activating the Wnt/β-catenin signaling pathway.Molecular and cellular biochemistry · 2024Article
- Ginsengenin derivatives synthesized from 20(Journal of ginseng research · 2022Article
- Application of triazoles in the structural modification of natural products.Journal of enzyme inhibition and medicinal chemistry · 2021Review
- Click Chemistry in Natural Product Modification.Frontiers in chemistry · 2021Review
- Synthesis and biological evaluation of ursolic acid derivatives bearing triazole moieties as potential anti-Toxoplasma gondii agents.Journal of enzyme inhibition and medicinal chemistry · 2019Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Six series of novel isosteviol derivatives; modified in the C-19 position; were synthesized; and their antiproliferative activity was evaluated against three human cancer cell lines (HCT-116; BEL-7402; HepG2) and the human L02 normal cell line in vitro. Most of the derivatives tested here exhibited improved antiproliferative activity with high selectivity when compared with the parent compound isosteviol and the positive control drug 5-fluorouracil. Among these derivatives; compound
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Registered trials
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