Evidence map›Paper›PMID 30598025›Full record

ArticleInternational journal of molecular sciences2018

Olive Biophenols Reduces Alzheimer's Pathology in SH-SY5Y Cells and APPswe Mice.

Syed Haris Omar, Christopher J Scott, Adam S Hamlin, Hassan K Obied

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed
3.7field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 66 citations in OpenAlex.

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  15. Reactive Oxygen Species andAntioxidants (Basel, Switzerland) · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Syed Haris OmarSchool of Biomedical Sciences, Faculty of Sciences and Graham Centre for Agricultural Innovation, Charles Sturt University, Wagga Wagga, NSW 2678, Australia. syedharisomar@gmail.com.ORCID 0000-0002-4955-5125
Christopher J ScottSchool of Biomedical Sciences, Faculty of Sciences and Graham Centre for Agricultural Innovation, Charles Sturt University, Wagga Wagga, NSW 2678, Australia. chscott@csu.edu.au.
Adam S HamlinSchool of Science & Technology, University of New England, Armidale, NSW 2351, Australia. ahamlin@une.edu.au.
Hassan K ObiedSchool of Biomedical Sciences, Faculty of Sciences and Graham Centre for Agricultural Innovation, Charles Sturt University, Wagga Wagga, NSW 2678, Australia. obiedhk@gmail.com.
Charles Sturt University · AUUniversity of New England · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Alzheimer's disease (AD) is a major neurodegenerative disease, associated with the hallmark proteinacious constituent called amyloid beta (Aβ) of senile plaques. Moreover, it is already established that metals (particularly copper, zinc and iron) have a key role in the pathogenesis of AD. In order to reduce the Aβ plaque burden and overcome the side effects from the synthetic inhibitors, the current study was designed to focus on direct inhibition of with or without metal-induced Aβ fibril formation and aggregation by using olive biophenols. Exposure of neuroblastoma (SH-SY5Y) cells with Aβ

Indexed as

Alzheimer DiseaseAmyloid beta-Protein PrecursorAnimalsCell Line, TumorGlucosidesHumansIridoid GlucosidesIridoidsMaleMiceNeuronsNeuroprotective AgentsOleaPhenolsPolyphenolsPresenilinsacteosideAmyloid beta-Protein PrecursorGlucosidesIridoid GlucosidesIridoidsNeuroprotective AgentsoleuropeinPhenolsPolyphenolsPresenilinsRutinAlzheimer’s diseaseamyloid betaoleuropeinolive biophenolsrutinSH-SY5Y cellsverbascoside

Identifiers

PMID30598025
PMCPMC6337485
OpenAlexW2906935376

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.