ArticleTransfusion2019
Platelet transfusions and mortality in necrotizing enterocolitis.
Article in Transfusion, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
15 citing papers in PubMed, 31 citations in OpenAlex.
- Erythropoietin prevents necrotizing enterocolitis in very preterm infants: a randomized controlled trial.Journal of translational medicine · 2020Trial
- Effects of platelet transfusions on neonatal bleeding and inflammation.Pediatric research · 2026Article
- Platelet Transfusions in Murine Models of Neonatal Thrombocytopenia.Methods in molecular biology (Clifton, N.J.) · 2026Article
- Miniaturized In Vitro Transfusion Model.Methods in molecular biology (Clifton, N.J.) · 2026Article
- Platelet Transfusions in Neonates: Beyond Hemostasis.Arteriosclerosis, thrombosis, and vascular biology · 2023Article
- Gestational age-specific hematological patterns in preterm infants following necrotizing enterocolitis.The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians · 2022Article
- Platelet transfusions in a murine model of neonatal polymicrobial sepsis: Divergent effects on inflammation and mortality.Transfusion · 2022Article
- Platelets in the neonate: Not just a small adult.Research and practice in thrombosis and haemostasis · 2022Article
- Neonatal platelet physiology and implications for transfusion.Platelets · 2022Review
- Hematological predictors of mortality in neonates with fulminant necrotizing enterocolitis.Journal of perinatology : official journal of the California Perinatal Association · 2021Article
- Transfusion in Neonatal Patients: Review of Evidence-Based Guidelines.Clinics in laboratory medicine · 2021Review
- Hemostatic Challenges in Neonates.Frontiers in pediatrics · 2021Review
- New directions in necrotizing enterocolitis with early-stage investigators.Pediatric research · 2020Review
- Transfusion-related Gut Injury and Necrotizing Enterocolitis.Clinics in perinatology · 2020Review
- Neonatal and pediatric platelet transfusions: current concepts and controversies.Current opinion in hematology · 2019Review
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundPrior studies have suggested an association between platelet transfusions (PTXs) and worse outcomes among infants with necrotizing enterocolitis (NEC), potentially mediated by proinflammatory factors released by platelets. However, the effects of storage on platelet proinflammatory factor release and the confounding role of illness severity on NEC outcomes have not been determined. STUDY DESIGN AND
methodsFirst, neuropeptide Y (a potent splanchnic vasoconstrictor released by platelets) was measured by enzyme-linked immunosorbent assay in fresh frozen plasma and in the supernatant of leukoreduced apheresis-derived platelets at different times during storage. Next, we evaluated the relationship between PTX rates and death in a multicenter cohort of very-low-birth-weight infants with NEC, adjusting for illness severity.
resultsNeuropeptide Y levels increased over time in the supernatant of leukoreduced apheresis-derived platelets and were 4.4-fold and 8.9-fold higher than in fresh frozen plasma on Days 2 and 3 of storage, respectively (p < 0.001). Among 598 very-low-birth-weight infants, 44 developed NEC. In unadjusted analysis, PTX rate was 30.3 (95% confidence interval [CI], 11.5-80.1) per 100 infant-days among infants who died, compared to 6.0 (95% CI, 3.2-11.2) among survivors (incidence rate ratio, 5.1; 95% CI, 1.6-16.2; p = 0.006). In multivariable analysis, there was no association between PTX rate and mortality (incidence rate ratio, 3.0; 95% CI, 0.6-15.0; p = 0.18), although estimation was imprecise.
conclusionProinflammatory mediators accumulate in platelet suspensions during storage. Although PTX rates were not associated with increased mortality among infants with NEC in our study, our estimates suggest the potential for such an association that needs evaluation in larger studies.
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Registered trials
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