ArticleNeuroImage2019
Task activations produce spurious but systematic inflation of task functional connectivity estimates.
Article in NeuroImage, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 145 papers.
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Who cites it
145 citing papers in PubMed.
- Intrinsic reward circuit connectivity profiles underlying symptom and quality of life outcomes following antidepressant medication: a report from the iSPOT-D trial.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2021Trial
- TMS-induced modulation of brain networks and its associations to rTMS treatment for depression: a concurrent fMRI-EEG-TMS study.Brain stimulationTrial
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- Narrative coherence shapes functional connectivity in default mode and frontoparietal networks.Neuroimage. Reports · 2026Article
- A cortical gradient in area 55b links language and somato-cognitive action networks.Research square · 2026Article
- Frontoparietal Hub Connectivity Integrates Information from Multiple Sources.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Multi-Scale Structural MRI Features Reveal Task-Based Functional Connectivity and Its Alterations in Psychiatric Disorders: A Collaborative Graph Attention Network Approach.Brain topography · 2026Article
- Estimating trial-wise modulation of functional connectivity using event-related fMRI.bioRxiv : the preprint server for biology · 2026Article
- Functional connectivity gradients depend on cortical sampling position and brain state.bioRxiv : the preprint server for biology · 2026Article
- Context-dependent reconfiguration of functional connectivity in posterior (VWFA-1) and anterior (VWFA-2) visual word form area under attentional and linguistic demands.Behavioral and brain functions : BBF · 2026Article
- Using connectome-based predictive models to reveal the systems standardized tests and clinical symptoms are reflecting.Nature communications · 2026Article
- Neurophysiological Functional Connectivity Changes during Difficult Listening in Older and Younger Adults.bioRxiv : the preprint server for biology · 2026Article
- Supervised Domain Adaptation Mitigates Cross-Ethnicity Prediction Error in Neuroimaging-Based Cognitive Prediction.bioRxiv : the preprint server for biology · 2026Article
- Leveraging Task FMRI Data to Extract Resting-State Metrics in Brain Tumor and Healthy Populations.Clinical neuroradiology · 2026Article
- An Examination of Task-Evoked fMRI Data Processing in Functional Connectivity.Journal of neuroscience research · 2026Article
- Frontoparietal Hub Connectivity Integrates Information from Multiple Sources.bioRxiv : the preprint server for biology · 2026Article
- Trait-Relevant Tasks Improve Personality Prediction From Structural-Functional Brain Network Coupling.Human brain mapping · 2026Article
- A rest-task fMRI study of spatial working memory in HIV-infected individuals across cognitive states.BMC medical imaging · 2026Article
- Neurocognitive characterization of behaviour and mental illness through time-varying brain network analysis.Nature communications · 2026Article
- Human brain network for reading the mind from the eyes: beyond activated and deactivated regions.Social cognitive and affective neuroscience · 2026Article
85 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Most neuroscientific studies have focused on task-evoked activations (activity amplitudes at specific brain locations), providing limited insight into the functional relationships between separate brain locations. Task-state functional connectivity (FC) - statistical association between brain activity time series during task performance - moves beyond task-evoked activations by quantifying functional interactions during tasks. However, many task-state FC studies do not remove the first-order effect of task-evoked activations prior to estimating task-state FC. It has been argued that this results in the ambiguous inference "likely active or interacting during the task", rather than the intended inference "likely interacting during the task". Utilizing a neural mass computational model, we verified that task-evoked activations substantially and inappropriately inflate task-state FC estimates, especially in functional MRI (fMRI) data. Various methods attempting to address this problem have been developed, yet the efficacies of these approaches have not been systematically assessed. We found that most standard approaches for fitting and removing mean task-evoked activations were unable to correct these inflated correlations. In contrast, methods that flexibly fit mean task-evoked response shapes effectively corrected the inflated correlations without reducing effects of interest. Results with empirical fMRI data confirmed the model's predictions, revealing activation-induced task-state FC inflation for both Pearson correlation and psychophysiological interaction (PPI) approaches. These results demonstrate that removal of mean task-evoked activations using an approach that flexibly models task-evoked response shape is an important preprocessing step for valid estimation of task-state FC.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.