Evidence map›Paper›PMID 30597195›Full record

ArticleFree radical biology & medicine2019

Improving mitochondrial function with SS-31 reverses age-related redox stress and improves exercise tolerance in aged mice.

Matthew D Campbell, Jicheng Duan, Ashton T Samuelson, Matthew J Gaffrey, Gennifer E Merrihew, Jarrett D Egertson, Lu Wang, Theo K Bammler, Ronald J Moore, Collin C White and 7 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Free radical biology & medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 92 papers.

0numbers the graph read from it
0cells of the map it votes in
92citing papers in PubMed
5.5field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

92 citing papers in PubMed, 135 citations in OpenAlex.

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  19. Contemporary insights into elamipretide's mitochondrial mechanism of action and therapeutic effects.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2025
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32 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 3 institutions in 1 country.

Matthew D CampbellDepartment of Radiology, University of Washington, Seattle, WA, USA. Electronic address: mdcampbe@uw.edu.
Jicheng DuanBiological Sciences Division, Pacific Northwest National Laboratory, Richland, WA, USA. Electronic address: jicheng.duan@bioverativ.com.
Ashton T SamuelsonDepartment of Radiology, University of Washington, Seattle, WA, USA. Electronic address: ats95@uw.edu.
Matthew J GaffreyBiological Sciences Division, Pacific Northwest National Laboratory, Richland, WA, USA. Electronic address: Matthew.Gaffrey@pnnl.gov.
Gennifer E MerrihewDepartment of Genome Sciences, University of Washington, Seattle, WA, USA. Electronic address: genn@uw.edu.
Jarrett D EgertsonDepartment of Genome Sciences, University of Washington, Seattle, WA, USA. Electronic address: jegertso@uw.edu.
Lu WangDepartment of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA, USA. Electronic address: lwang3@uw.edu.
Theo K BammlerDepartment of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA, USA. Electronic address: tbammler@uw.edu.
Ronald J MooreBiological Sciences Division, Pacific Northwest National Laboratory, Richland, WA, USA. Electronic address: ronald.moore@pnnl.gov.
Collin C WhiteDepartment of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA, USA. Electronic address: ccwhite@uw.edu.
Terrance J KavanaghDepartment of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA, USA. Electronic address: tjkav@uw.edu.
Joachim G VossSchool of Nursing, University of Washington, Seattle, WA, USA. Electronic address: jgv20@case.edu.
Hazel H SzetoSocial Profit Network, Menlo Park, CA, USA.
Peter S RabinovitchDepartment of Pathology, University of Washington, Seattle, WA, USA. Electronic address: petersr@uw.edu.
Michael J MacCossDepartment of Genome Sciences, University of Washington, Seattle, WA, USA. Electronic address: maccoss@uw.edu.
Wei-Jun QianSchool of Nursing, University of Washington, Seattle, WA, USA. Electronic address: Weijun.Qian@pnnl.gov.
David J MarcinekDepartment of Radiology, University of Washington, Seattle, WA, USA. Electronic address: dmarc@uw.edu.
University of Washington · USPacific Northwest National Laboratory · USMeta (United States) · US

Funding

XENOBIOTIC BIOTRANSFORMATION AND DISPOSITIONP30ES007033 · NIEHS · UNIVERSITY OF WASHINGTON · PI ALI SHOJAIE · 1995 to 2026
$42.5M
SPECIFICITY OF OXYGEN DNA DAMAGE AND MUTAGENESISP01AG001751 · NIA · UNIVERSITY OF WASHINGTON · PI RABINOVITCH, PETER S · 1985 to 2021
$29.6M
University of Washington Nathan Shock Center of Excellence in the Basic Biology of AgingP30AG013280 · NIA · UNIVERSITY OF WASHINGTON · PI Su-In Lee · 1995 to 2026
$27.1M
GENETIC APPROACHES TO AGING RESEARCHT32AG000057 · NIA · UNIVERSITY OF WASHINGTON · PI RABINOVITCH, PETER S · 1985 to 2019
$14.2M
A novel antibody based biomarker for toxicity of chronic domoic acid exposureR01ES021930 · NIEHS · UNIVERSITY OF WASHINGTON · PI LEFEBVRE, KATHI, MARCINEK, DAVID J. · 2012 to 2016
$874k
SS peptides: improve mitochondrial and skeletal muscle function with ageR21AG042637 · NIA · UNIVERSITY OF WASHINGTON · PI MARCINEK, DAVID J. · 2012 to 2013
$480k
NIA NIH HHS P01 AG001751NIA NIH HHS P30 AG013280NIA NIH HHS R21 AG042637NIA NIH HHS T32 AG000057NIEHS NIH HHS P30 ES007033NIEHS NIH HHS R01 ES021930
6 · The paper itself

Abstract

Sarcopenia and exercise intolerance are major contributors to reduced quality of life in the elderly for which there are few effective treatments. We tested whether enhancing mitochondrial function and reducing mitochondrial oxidant production with SS-31 (elamipretide) could restore redox balance and improve skeletal muscle function in aged mice. Young (5 mo) and aged (26 mo) female C57BL/6Nia mice were treated for 8-weeks with 3 mg/kg/day SS-31. Mitochondrial function was assessed in vivo using

Indexed as

AgingAnimalsExercise ToleranceFemaleGlutathioneMiceMice, Inbred C57BLMitochondriaMitochondrial ProteinsMuscle, SkeletalOligopeptidesOxidation-ReductionOxidative PhosphorylationOxidative StressPhysical Conditioning, Animalarginyl-2,'6'-dimethyltyrosyl-lysyl-phenylalaninamideGlutathioneMitochondrial ProteinsOligopeptidesAgingFatigueMitochondriaOxidative stressSkeletal muscle

Identifiers

PMID30597195
PMCPMC6588449
OpenAlexW2908316563

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.