Evidence map›Paper›PMID 30597109›Full record

ArticleNucleic acids research2019

Differential regulation of RNA polymerase III genes during liver regeneration.

Meghdad Yeganeh, Viviane Praz, Cristian Carmeli, Dominic Villeneuve, Leonor Rib, Nicolas Guex, Winship Herr, Mauro Delorenzi, Nouria Hernandez, CycliX consortium

Open access · goldAbstract read
In one paragraph

Article in Nucleic acids research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
0.8field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. RNA Polymerases I and III in development and disease.Seminars in cell & developmental biology · 2023
    Review
  7. Article
  8. RNA Polymerase III, Ageing and Longevity.Frontiers in genetics · 2021
    Review
  9. Article
  10. Article
  11. Functions of paralogous RNA polymerase III subunits POLR3G and POLR3GL in mouse development.Proceedings of the National Academy of Sciences of the United States of America · 2020
    Article
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Meghdad YeganehCenter for Integrative Genomics, Faculty of Biology and Medicine, University of Lausanne, 1015 Lausanne, Switzerland.
Viviane PrazCenter for Integrative Genomics, Faculty of Biology and Medicine, University of Lausanne, 1015 Lausanne, Switzerland.
Cristian CarmeliCenter for Integrative Genomics, Faculty of Biology and Medicine, University of Lausanne, 1015 Lausanne, Switzerland.
Dominic VilleneuveCenter for Integrative Genomics, Faculty of Biology and Medicine, University of Lausanne, 1015 Lausanne, Switzerland.
Leonor RibCenter for Integrative Genomics, Faculty of Biology and Medicine, University of Lausanne, 1015 Lausanne, Switzerland.
Nicolas GuexSIB Swiss Institute of Bioinformatics, 1015 Lausanne, Switzerland.
Winship HerrCenter for Integrative Genomics, Faculty of Biology and Medicine, University of Lausanne, 1015 Lausanne, Switzerland.
Mauro DelorenziBioinformatics Core Facility, SIB Swiss Institute of Bioinformatics, 1015 Lausanne, Switzerland.
Nouria HernandezCenter for Integrative Genomics, Faculty of Biology and Medicine, University of Lausanne, 1015 Lausanne, Switzerland.
CycliX consortium
SIB Swiss Institute of Bioinformatics · CHUniversity of Lausanne · CHÉcole Polytechnique Fédérale de Lausanne · CHUniversity of Geneva · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mouse liver regeneration after partial hepatectomy involves cells in the remaining tissue synchronously entering the cell division cycle. We have used this system and H3K4me3, Pol II and Pol III profiling to characterize adaptations in Pol III transcription. Our results broadly define a class of genes close to H3K4me3 and Pol II peaks, whose Pol III occupancy is high and stable, and another class, distant from Pol II peaks, whose Pol III occupancy strongly increases after partial hepatectomy. Pol III regulation in the liver thus entails both highly expressed housekeeping genes and genes whose expression can adapt to increased demand.

Indexed as

Transcription, GeneticAnimalsCell CycleCell DivisionChromatin ImmunoprecipitationGene Expression Regulation, DevelopmentalHepatectomyHistone-Lysine N-MethyltransferaseHistonesHumansLiverLiver RegenerationMiceProtein BindingRNA Polymerase IIRNA Polymerase IIIhistone H3 trimethyl Lys4Histone-Lysine N-MethyltransferaseHistonesRNA Polymerase IIRNA Polymerase III

Identifiers

PMID30597109
PMCPMC6393285
OpenAlexW2908130330

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.