ArticleInternational health2020
From risk to care: the hepatitis C screening and diagnostic cascade in a primary health care clinic in Karachi, Pakistan-a cohort study.
Article in International health, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 2 of them syntheses that pooled it.
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Who cites it
14 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Impact of hepatitis C virus point-of-care RNA viral load testing compared with laboratory-based testing on uptake of RNA testing and treatment, and turnaround times: a systematic review and meta-analysis.The lancet. Gastroenterology & hepatology · 2023Pooled it
- Meta-analysis: risk of hepatitis C virus infection associated with hospital-based invasive procedures.Alimentary pharmacology & therapeutics · 2022Pooled it
- Economic evaluation of an employee health screening program for Hepatitis C virus in Pakistan.Cost effectiveness and resource allocation : C/E · 2025Article
- Article
- Hepatitis is still a major health concern in Pakistan: short communication.Annals of medicine and surgery (2012) · 2023Article
- Article
- Prevalence and risk factors for hepatitis C virus infection in an informal settlement in Karachi, Pakistan.PLOS global public health · 2023Article
- Outcomes of the CT2 study: A 'one-stop-shop' for community-based hepatitis C testing and treatment in Yangon, Myanmar.Liver international : official journal of the International Association for the Study of the Liver · 2021Article
- Health and economic benefits of achieving hepatitis C virus elimination in Pakistan: A modelling study and economic analysis.PLoS medicine · 2021Article
- Cost-effectiveness of screening and treatment using direct-acting antivirals for chronic Hepatitis C virus in a primary care setting in Karachi, Pakistan.Journal of viral hepatitis · 2021Article
- Predictive factors for acquiring HCV infection in the population residing in high endemic, resource-limited settings.Journal of family medicine and primary care · 2021Article
- Relationship of FIB-4 index with transient elastography in chronic hepatitis C patients having APRI ≥ 0.5 - ≤2 in a resource-limited setting in Pakistan.Journal of family medicine and primary care · 2020Article
- Decentralized, Community-Based Hepatitis C Point-of-Care Testing and Direct-Acting Antiviral Treatment for People Who Inject Drugs and the General Population in Myanmar: Protocol for a Feasibility Study.JMIR research protocols · 2020Article
- Effects and cost of different strategies to eliminate hepatitis C virus transmission in Pakistan: a modelling analysis.The Lancet. Global health · 2020Article
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Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIn the high-prevalence setting of Pakistan, screening, diagnosis and treatment services for chronic hepatitis C (CHC) patients are commonly offered in specialized facilities. We aimed to describe the cascade of care in a Médecins Sans Frontières primary health care clinic offering CHC care in an informal settlement in Karachi, Pakistan.
methodsThis was a retrospective cohort analysis using routinely collected data. Three different screening algorithms were assessed among patients with one or more CHC risk factors.
resultsAmong the 87 348 patients attending the outpatient clinic, 5003 (6%) presented with one or more risk factors. Rapid diagnostic test (RDT) positivity was 38% overall. Approximately 60% of the CHC patients across all risk categories were in the early stage of the disease, with an aspartate aminotransferase:platelet ratio index score <1. The sequential delays in the cascade differed between the three groups, with the interval between screening and treatment initiation being the shortest in the cohort tested with GeneXpert onsite.
conclusionsDelays between screening and treatment can be reduced by putting in place more patient-centric testing algorithms. New strategies, to better identify and treat the hidden at-risk populations, should be developed and implemented.
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