Evidence map›Paper›PMID 30596405›Full record

ArticleBritish journal of haematology2018

Direct role of FLT3 in regulation of early lymphoid progenitors.

Alya Zriwil, Charlotta Böiers, Trine A Kristiansen, Lilian Wittmann, Joan Yuan, Claus Nerlov, Ewa Sitnicka, Sten E W Jacobsen

Open access · hybridAbstract read
In one paragraph

Article in British journal of haematology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
0.7field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 19 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. The Pleiotropy ofInternational journal of molecular sciences · 2022
    Review
  10. Flt3 Signaling in B Lymphocyte Development and Humoral Immunity.International journal of molecular sciences · 2022
    Review
  11. Article
  12. Lymphomagenesis predictors and related pathogenesis.Journal of translational autoimmunity · 2021
    Review
  13. Risk assessment ofPeerJ · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Alya ZriwilLund Center for Stem Cell Biology and Cell Therapy, Lund University, Lund, Sweden.
Charlotta BöiersMolecular Medicine and Gene Therapy, Lund Stem Cell Center, Lund University, Lund, Sweden.
Trine A KristiansenDivision of Molecular Haematology, Department of Laboratory Medicine, Lund University, Lund, Sweden.
Lilian WittmannLund Center for Stem Cell Biology and Cell Therapy, Lund University, Lund, Sweden.
Joan YuanDivision of Molecular Haematology, Department of Laboratory Medicine, Lund University, Lund, Sweden.
Claus NerlovMRC Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, Oxford, United Kingdom.
Ewa SitnickaLund Center for Stem Cell Biology and Cell Therapy, Lund University, Lund, Sweden.ORCID 0000-0001-5332-7048
Sten E W JacobsenMRC Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, Oxford, United Kingdom.
Lund University · SEJohn Radcliffe Hospital · GBKarolinska University Hospital · SE

Funding

Medical Research Council G0501838Medical Research Council G0701761Medical Research Council G0801073Medical Research Council G0900892Medical Research Council MC_UU_00016/5Medical Research Council MC_UU_00016/7Medical Research Council MC_UU_12009/5Medical Research Council MC_UU_12009/7
6 · The paper itself

Abstract

Given that FLT3 expression is highly restricted on lymphoid progenitors, it is possible that the established role of FLT3 in the regulation of B and T lymphopoiesis reflects its high expression and role in regulation of lymphoid-primed multipotent progenitors (LMPPs) or common lymphoid progenitors (CLPs). We generated a Flt3 conditional knock-out (Flt3

Indexed as

Cell DifferentiationLymphopoiesisAnimalsBone Marrow Cellsfms-Like Tyrosine Kinase 3Homeodomain ProteinsLymphoid Progenitor CellsMiceMice, KnockoutPrecursor B-Cell Lymphoblastic Leukemia-LymphomaThymus GlandFlt3 protein, mousefms-Like Tyrosine Kinase 3Homeodomain ProteinsRAG-1 proteinconditional knock‐out mouse modelFLT3haematopoiesislymphoid developmentlymphoid progenitors

Identifiers

PMID30596405
PMCPMC6492191
OpenAlexW2892220666

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.