Evidence map›Paper›PMID 30596334›Full record

ReviewJournal of environmental science and health. Part C, Environmental carcinogenesis & ecotoxicology reviews2019

Polycyclic aromatic hydrocarbons as a potential source of carcinogenicity of mate.

Ebele Oranuba, Hua Deng, Jiangnan Peng, Sanford M Dawsey, Farin Kamangar

Abstract readReview
In one paragraph

Review in Journal of environmental science and health. Part C, Environmental carcinogenesis & ecotoxicology reviews, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
2.1field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 29 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Ebele Oranubaa ASCEND Center for Biomedical Research , Morgan State University , Baltimore , MD , USA.
Hua Dengb Department of Chemistry, School of Computer, Mathematical, and Natural Sciences , Morgan State University , Baltimore , MD , USA.
Jiangnan Pengb Department of Chemistry, School of Computer, Mathematical, and Natural Sciences , Morgan State University , Baltimore , MD , USA.
Sanford M Dawseyc Metabolic Epidemiology Branch, Division of Cancer Epidemiology and Genetics , National Cancer Institute, National Institutes of Health , Bethesda , MD , USA.
Farin Kamangara ASCEND Center for Biomedical Research , Morgan State University , Baltimore , MD , USA.
Morgan State University · USNational Cancer Institute · US

Funding

Upper Gastrointestinal Cancer StudiesZIACP000185 · NCI · DIVISION OF CANCER EPIDEMIOLOGY AND GENETICS · PI ABNET, CHRISTIAN · 2009 to 2025
$25.6M
Project-002UL1GM118973 · NIGMS · MORGAN STATE UNIVERSITY · PI HOHMANN, CHRISTINE F, SHEIKHATTARI, PAYAM · 2015 to 2023
$18.8M
NIGMS NIH HHS UL1 GM118973
6 · The paper itself

Abstract

Drinking mate, an infusion of the herb ilex paraguariensis, is very common in several South American countries, and has been associated with an increased risk of esophageal cancer. This increased risk may be attributed to drinking mate very hot, or to mate's potentially carcinogenic contaminants, such as polycyclic aromatic hydrocarbons (PAHs). Mate leaves are often dried via smoking, and therefore commercial samples may have high amounts of PAHs. We found 10 original articles that had measured PAHs in commercial dry samples, and nearly all found very high mass fractions. Most studies found benzo[a]pyrene mass fractions to be over 25 ng/g, and some found levels up to 600 ng/g. However, carcinogenic PAHs are often hydrophobic, and may not readily transfer into infusions. Seven articles studied transfer rates, and these rates varied from 1 to 50%, depending on the methods employed. Further careful studies of transfer rates in situations that mimic real life drinking of mate are recommended. Also, further studies of biological indicators of PAH exposure, particularly in randomized experiments, and analyzing DNA from tumor samples of mate drinkers are recommended.

Indexed as

CarcinogensDrinkingEnvironmental ExposureHumansIlex paraguariensisPlant LeavesPolycyclic Aromatic HydrocarbonsCarcinogensPolycyclic Aromatic Hydrocarbonsbenzo[a]pyreneesophageal cancerhot drinksmatePAH

Identifiers

PMID30596334
PMCPMC6443446
OpenAlexW2907340076

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.