Evidence map›Paper›PMID 30596225›Full record

ArticleInfluenza and other respiratory viruses2019

Burden and epidemiology of influenza- and respiratory syncytial virus-associated severe acute respiratory illness hospitalization in Madagascar, 2011-2016.

Joelinotahina H Rabarison, Stefano Tempia, Aina Harimanana, Julia Guillebaud, Norosoa H Razanajatovo, Maherisoa Ratsitorahina, Jean-Michel Heraud

Open access · goldAbstract read
In one paragraph

Article in Influenza and other respiratory viruses, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed, 3 pooled it
4.5field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 3 syntheses or guidelines pooled it, 50 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 6 countries.

Joelinotahina H RabarisonNational Influenza Centre, Virology Unit, Institut Pasteur de Madagascar, Antananarivo, Madagascar.
Stefano TempiaInfluenza Division, National Center for Immunization and Respiratory Diseases, US Centers for Disease Control and Prevention, Atlanta, Georgia.ORCID 0000-0003-4395-347X
Aina HarimananaEpidemiology Unit, Institut Pasteur de Madagascar, Antananarivo, Madagascar.
Julia GuillebaudNational Influenza Centre, Virology Unit, Institut Pasteur de Madagascar, Antananarivo, Madagascar.
Norosoa H RazanajatovoNational Influenza Centre, Virology Unit, Institut Pasteur de Madagascar, Antananarivo, Madagascar.
Maherisoa RatsitorahinaDirection de la Veille Sanitaire et de la Surveillance Epidemiologique, Ministry of Public Health, Antananarivo, Madagascar.
Jean-Michel HeraudNational Influenza Centre, Virology Unit, Institut Pasteur de Madagascar, Antananarivo, Madagascar.ORCID 0000-0003-1107-0859
Institut Pasteur de Madagascar · MGCenters for Disease Control and Prevention · USInstitut de Veille Sanitaire · FRInstitut Pasteur · FR

Funding

Sustaining Surveillance Networks and Response to Seasonal and Pandemic Influenza U51IP000812 · IP · PASTEUR INSTITUTE FROM MADAGASCAR · PI HERAUD, JEAN-MICHEL · 2013 to 2015
$1.5M
Investigating seasonal drivers of viral zoonoses from Madagascar fruit batsR01AI129822 · NIAID · PASTEUR INSTITUTE FROM MADAGASCAR · PI DUSSART, PHILIPPE · 2017 to 2021
$674k
NCIRD CDC HHS U51 IP000812NIAID NIH HHS R01 AI129822US Centers for Disease Control and Prevention U51IP000812-05
6 · The paper itself

Abstract

backgroundInfluenza and respiratory syncytial virus (RSV) infections are responsible for substantial global morbidity and mortality in young children and elderly individuals. Estimates of the burden of influenza- and RSV-associated hospitalization are limited in Africa.

methodsWe conducted hospital-based surveillance for laboratory-confirmed influenza- and RSV-associated severe acute respiratory illness (SARI) among patients of any age at one hospital and a retrospective review of SARI hospitalizations in five hospitals situated in Antananarivo during 2011-2016. We estimated age-specific rates (per 100 000 population) of influenza- and RSV-associated SARI hospitalizations for the Antananarivo region and then extrapolated these rates to the national level.

resultsOverall, the mean annual national number of influenza-associated SARI hospitalizations for all age groups was 6609 (95% CI: 5381-7835-rate: 30.0; 95% CI: 24.4-35.6), 4468 (95% CI: 3796-5102-rate: 127.6; 95% CI: 108.4-145.7), 2141 (95% CI: 1585-2734-rate: 11.6; 95% CI: 8.6-14.8), and 339 (95% CI: 224-459-rate: 50.0; 95% CI: 36.3-74.4) among individuals aged <5, ≥5, and ≥65 years, respectively. For these same age groups, the mean annual number of RSV-associated SARI hospitalizations was 11 768 (95% CI: 10 553-12 997-rate: 53.4; 95% CI: 47.9-59.0), 11 299 (95% CI: 10 350-12 214-rate: 322.7; 95% CI: 295.6-348.8), 469 (95% CI: 203-783-rate: 2.5;95% CI: 1.1-4.2), and 36 (95% CI: 0-84-rate: 5.8; 0.0-13.5), respectively.

conclusionThe burden of influenza- and RSV-associated SARI hospitalization was high among children aged <5 years. These first estimates for Madagascar will enable government to make informed evidence-based decisions when allocating scarce resources and planning intervention strategies to limit the impact and spread of these viruses.

Indexed as

Cost of IllnessAcute DiseaseAdolescentAdultAgedChildChild, PreschoolFemaleHospitalizationHumansInfantInfluenza, HumanMadagascarMaleMiddle AgedRespiratory Syncytial Virus InfectionsAfricadisease burdenhospitalizationinfluenzaMadagascarrespiratory syncytial virus

Identifiers

PMID30596225
PMCPMC6379640
OpenAlexW2795563619

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.