Evidence map›Paper›PMID 30596168›Full record

ArticleKidney international reports2019

Clinical Manifestations and Long-term Outcomes of IgG4-Related Kidney and Retroperitoneal Involvement in a United Kingdom IgG4-Related Disease Cohort.

Rhys D R Evans, Tamsin Cargill, George Goodchild, Ben Oliveira, Manuel Rodriguez-Justo, Ruth Pepper, John Connolly, Alan Salama, George Webster, Eleanor Barnes and 1 more

Open access · goldAbstract read
In one paragraph

Article in Kidney international reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 1 pooled it
4.0field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 1 synthesis or guideline pooled it, 46 citations in OpenAlex.

  1. Pooled it
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  10. Renal Manifestations of IgG4-Related Disease: A Concise Review.International journal of nephrology · 2024
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 1 country.

Rhys D R EvansUniversity College London Centre for Nephrology, Royal Free Hospital, London, UK.
Tamsin CargillTranslational Gastroenterology Unit, John Radcliffe Hospital, and Nuffield Department of Medicine, University of Oxford, Oxford, UK.
George GoodchildGastroenterology Department, University College London Hospital NHS Trust, London, UK.
Ben OliveiraUniversity College London Centre for Nephrology, Royal Free Hospital, London, UK.
Manuel Rodriguez-JustoHistopathology Department, University College London Hospital NHS Trust, London, UK.
Ruth PepperUniversity College London Centre for Nephrology, Royal Free Hospital, London, UK.
John ConnollyUniversity College London Centre for Nephrology, Royal Free Hospital, London, UK.
Alan SalamaUniversity College London Centre for Nephrology, Royal Free Hospital, London, UK.
George WebsterGastroenterology Department, University College London Hospital NHS Trust, London, UK.
Eleanor BarnesTranslational Gastroenterology Unit, John Radcliffe Hospital, and Nuffield Department of Medicine, University of Oxford, Oxford, UK.
Emma L CulverTranslational Gastroenterology Unit, John Radcliffe Hospital, and Nuffield Department of Medicine, University of Oxford, Oxford, UK.
University College London · GBThe Royal Free Hospital · GBUniversity of Oxford · GBJohn Radcliffe Hospital · GBUniversity College Hospital · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionIgG4-related disease (IgG4-RD) is a relapsing multisystem fibro-inflammatory disease, which may involve the kidney (IgG4-related kidney disease [IgG4-RKD]) and retroperitoneum (IgG4-related retroperitoneal fibrosis [IgG4-RPF]). The aim of this study was to describe IgG4-RKD and IgG4-RPF in the United Kingdom.

methodsWe conducted a retrospective observational study of patients with IgG4-RKD and IgG4-RPF in a multicenter IgG4-RD cohort. Data were collected through review of medical records. We describe clinical parameters at baseline, histological and radiological findings, treatment, and patient outcomes.

resultsOf 154 patients with IgG4-RD, 14 (9.1%) had IgG4-RKD, 10 (6.5%) had IgG4-RPF, and 4 (2.6%) had both. Patients were aged 58.2 ± 14.2 years, and 26 (92.9%) were male. Creatinine at presentation was worse in those with intrinsic renal disease (229 μmol/l vs. 110 μmol/l;

conclusionIgG4-RKD and IgG4-RPF represent major organ manifestations of IgG4-RD, and should be identified early with prompt treatment to prevent progression to ESRD.

Indexed as

IgG4-related diseasemembranous nephropathyretroperitoneal fibrosistubulointerstitial nephritis

Identifiers

PMID30596168
PMCPMC6308386
OpenAlexW2889194162

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.