ArticleBioMed research international2018
Evaluation of a Porous Bioabsorbable Interbody Mg-Zn Alloy Cage in a Goat Cervical Spine Model.
Article in BioMed research international, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Advancements in biomaterials and bioactive solutions for lumbar spine fusion cages: Current trends and future perspectives.Bioactive materials · 2025Review
- BIOABSORBABLE CAGES IN SPINAL FUSION IN AN ANIMAL MODEL: A SYSTEMATIC REVIEW AND META-ANALYSIS.Acta ortopedica brasileira · 2025Review
- A novel porous interbody fusion cage modified by microarc oxidation and hydrothermal treatment technology accelerate osseointegration and spinal fusion in sheep.RSC advances · 2024Article
- Magnesium-based alloys with adapted interfaces for bone implants and tissue engineering.Regenerative biomaterials · 2023Review
- Fluoride-coated high-purity magnesium cage promotes bone fusion in goat models.Annals of translational medicine · 2022Article
- Preliminary results in anterior cervical discectomy and fusion with the uncovertebral joint fusion cage in a goat model.BMC musculoskeletal disorders · 2021Article
- Lumbar Interbody Fusion Conducted on a Porcine Model with a Bioresorbable Ceramic/Biopolymer Hybrid Implant Enriched with Hyperstable Fibroblast Growth Factor 2.Biomedicines · 2021Article
- Bioabsorbable high-purity magnesium interbody cage: degradation, interbody fusion, and biocompatibility from a goat cervical spine model.Annals of translational medicine · 2020Article
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10 authors.
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Abstract
purposeBioabsorbable Mg-based implants were previously assessed due to their intrinsic advantages, but Mg-based cage related research is limited. The specific blood supply and stress of the intervertebral environment can affect the function of Mg-based implants. The objective of this study was to investigate the performance of a bioabsorbable Mg-Zn alloy cage in anterior cervical discectomy and fusion (ACDF) and evaluate the control of degradation of the Mg-Zn cage surface modified by microarc oxidation (MAO) technology containing Si under an intervertebral microenvironment.
methodsTwenty-four goats were divided into four groups according to the experimental period and all underwent ACDF at C2-3 and C4-5 with porous Mg-Zn cage covered with a MAO/Si-containing coating in one intervertebral space and with autologous iliac bone in another space. After 3, 6, 12, or 24 weeks after operation, the cervical spine specimens were harvested to evaluate the biocompatibility, fusion status, and degradation conditions using blood analysis, radiology, biomechanical testing, histology, and micro-CT.
resultsThe Mg-Zn cages showed ideal biocompatibility and biomechanical characterization; however, the fusion state, as evaluated with radiology and histology, was not acceptable. Modified by the MAO/Si-containing coating, the degradation rate of the Mg-Zn cages was controllable but slower than expected.
conclusionMAO/Si-containing coating Mg-Zn alloy cages demonstrated excessive control of degradation and fusion failure after 24 weeks postoperatively. We conclude that further studies should be designed to improve the using of Mg-based materials at the intervertebral space.
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