ArticleJournal of International Society of Preventive & Community Dentistry
Expression of P53 Protein and Ki-67 Antigen in Oral Leukoplakia with Different Histopathological Grades of Epithelial Dysplasia.
Article in Journal of International Society of Preventive & Community Dentistry. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 19 citations in OpenAlex.
- Cell Proliferation, DNA Damage, and Apoptosis in Oral Leukoplakia and Oral Squamous Cell Carcinoma in Young Patients: A Comparative Immunohistochemical Study.Head and neck pathology · 2025Article
- MicroRNA-Based Markers of Oral Tongue Squamous Cell Carcinoma and Buccal Squamous Cell Carcinoma.Cureus · 2025Article
- Expression of Ki-67 in Oral Lichen Planus: A Systematic Review and Meta-Analysis.Journal of dentistry (Shiraz, Iran) · 2024Review
- Potential Immunohistochemical Biomarkers for Grading Oral Dysplasia: A Literature Review.Biomedicines · 2024Review
- Podoplanin Expression Independently and Jointly with Oral Epithelial Dysplasia Grade Acts as a Potential Biomarker of Malignant Transformation in Oral Leukoplakia.Biomolecules · 2022Article
- Expression of p53, p63, podoplanin and Ki-67 in recurring versus non-recurring oral leukoplakia.Scientific reports · 2021Article
- Intralesional Infiltrations of Cell-Free Filtrates Derived from Human Diabetic Tissues Delay the Healing Process and Recreate Diabetes Histopathological Changes in Healthy Rats.Frontiers in clinical diabetes and healthcare · 2021Article
- Benign Alveolar Ridge Keratosis: Clinical and Histopathologic Analysis of 167 Cases.Head and neck pathology · 2020Article
- Application of Texture and Fractal Dimension Analysis to Estimate Effectiveness of Oral Leukoplakia Treatment Using an Er:YAG Laser-A Prospective Study.Materials (Basel, Switzerland) · 2020Article
- Theoretical Background to Automated Diagnosing of Oral Leukoplakia: A Preliminary Report.Journal of healthcare engineering · 2020Article
- Analysis of Ki-67 Expression in Oral Premalignant Lesions and Normal Oral Mucosa: An Immunohistochemical Study.Journal of pharmacy & bioallied sciences · 2019Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
AIMS AND
objectiveThe aim of this study is to investigate the expression of p53 protein and Ki-67 antigen in normal oral mucosa and oral leukoplakia with different grades of dysplasia using immunohistochemistry and to clarify the correlation of the expression of these cell cycle regulatory proteins. MATERIALS AND
methodsA total of 20 archival tissue blocks obtained from our department which were diagnosed as mild (
resultsAll samples showed positive staining for p53 and Ki-67. Statistically significant difference (
conclusionOral leukoplakia represents the most common oral potentially malignant disorder (OPMD). Molecular biological markers such as p53 and Ki-67 are considered to be of great value in the diagnosis and prognostic evaluation of OPMD. Our results emphasize the potential use of p53 protein and Ki-67 antigen as significant molecular markers for early detection of PMDs and its risk of developing oral squamous cell carcinoma.
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