Development and validation of an HPLC-UV method for analysis of methylphenidate hydrochloride and loxapine succinate in an activated carbon disposal system.

Pooja Bakshi, Andrew Korey, William Fowler, Ajay K Banga

Open access · goldAbstract read

In one paragraph

Article in Journal of pharmaceutical analysis, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it

0cells of the map it votes in

2citing papers in PubMed

0.2field-weighted citation impact, top 49% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 12 citations in OpenAlex.

Bibliometric Analysis and Review of Global Academic Research on Drug Take-Back Programs.Healthcare (Basel, Switzerland) · 2025
Review
Evaluating the feasibility of implementing a prescription drug misuse prevention intervention in the community: a mixed methods study.BMC public health · 2023
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Pooja BakshiDepartment of Pharmaceutical Sciences, Mercer University, Atlanta, GA 30341, USA.

Andrew KoreyVerde Environmental Technologies, 12900 Whitewater Drive, Minnetonka, MN 55343, USA.

William FowlerVerde Environmental Technologies, 12900 Whitewater Drive, Minnetonka, MN 55343, USA.

Ajay K BangaDepartment of Pharmaceutical Sciences, Mercer University, Atlanta, GA 30341, USA.

Environmental Technologies (United States) · USMercer University · USMercer University Health Sciences Center · US

Funding

NIDA NIH HHS HHSN271201400068C

6 · The paper itself

Abstract

Unused medications have the possibility of being abused, causing serious harm to individuals who were not prescribed the drug. The Food and Drug Administration (FDA) recommends the proper disposal of unused prescribed medications to maintain safety and prevent environmental hazards. However, many of the current disposal techniques do not properly address safety. A drug disposal pouch containing granular activated carbon offers a unique disposal method to deactivate residual or expired medication in a convenient, effective, and safe manner. A robust and validated method for methylphenidate hydrochloride and loxapine succinate was developed using high-performance liquid chromatography (HPLC) and the deactivation efficiency of the disposal system was tested. Methylphenidate hydrochloride was analyzed on a C

Indexed as

Activated carbonAnalytical method developmentFDA drug disposalLoxapine succinateMethylphenidate hydrochloride

Identifiers

PMID30595940

DOI10.1016/j.jpha.2017.12.002

PMCPMC6308021

OpenAlexW2775574985

What OpenQuestion holds

Textmetadata

LicenceCC BY-NC-ND

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.