Evidence map›Paper›PMID 30595897›Full record

ArticleCurrent health sciences journal

P53 Immunoexpression in Laryngeal Squamous Cell Carcinoma.

Liliana Cercelaru, A E Stepan, C Mărgăritescu, A Osman, Ionelia-Carmen Popa, Cristiana Eugenia Simionescu, Otilia Mărgăritescu

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Article in Current health sciences journal. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Liliana CercelaruDepartment of Pathology, University of Medicine and Pharmacy of Craiova, Romania.
A E StepanDepartment of Pathology, University of Medicine and Pharmacy of Craiova, Romania.
C MărgăritescuDepartment of Pathology, University of Medicine and Pharmacy of Craiova, Romania.
A OsmanDepartment of Anatomy, University of Medicine and Pharmacy of Craiova, Romania.
Ionelia-Carmen PopaDepartment of Pathology, University of Medicine and Pharmacy of Craiova, Romania.
Cristiana Eugenia SimionescuDepartment of Pathology, University of Medicine and Pharmacy of Craiova, Romania.
Otilia MărgăritescuDepartment of Neurosurgery, University of Medicine and Pharmacy of Craiova, Romania.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

p53 is a marker described in the premalignant lesions with a high risk of malignant transformation for laryngeal cancer. It is a tumor suppressor gene that during the cancer gains also oncogenic activity. We aimed to study the p53 immunoexpression in 38 cases of laryngeal squamous cell carcinomas and the relation with the clinicopathological aspects. We obtained variable p53 expression regarding the differentiation degree and tumor stage. The higher p53 immunotaining values were observed in high grade and advanced stages lesions. P53 may be useful in identifying aggresive laryngeal squamous carcinomas, a useful aspect for better stratification of patients for therapy.

Indexed as

laryngeal squamous cell carcinomap53

Identifiers

PMID30595897
PMCPMC6286461

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.