Evidence map›Paper›PMID 30595832›Full record

ArticleJournal of healthcare engineering2018

Nonmotile Single-Cell Migration as a Random Walk in Nonuniformity: The "Extreme Dumping Limit" for Cell-to-Cell Communications.

Grigorios P Panotopoulos, Sebastian Aguayo, Ziyad S Haidar

Abstract read
In one paragraph

Article in Journal of healthcare engineering, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Grigorios P PanotopoulosBioMAT'X, Facultad de Odontología, Universidad de Los Andes, Santiago, Chile.
Sebastian AguayoSchool of Dentistry, Pontificia Universidad Católica de Chile, Santiago, Chile.ORCID 0000-0003-0900-1993
Ziyad S HaidarBioMAT'X, Facultad de Odontología, Universidad de Los Andes, Santiago, Chile.ORCID 0000-0003-0077-2927

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In the present work, we model single-cell movement as a random walk in an external potential observed within the extreme dumping limit, which we define herein as the extreme nonuniform behavior observed for cell responses and cell-to-cell communications. Starting from the Newton-Langevin equation of motion, we solve the corresponding Fokker-Planck equation to compute higher moments of the displacement of the cell, and then we build certain quantities that can be measurable experimentally. We show that, each time, the dynamics depend on the external force applied, leading to predictions distinct from the standard results of a free Brownian particle. Our findings demonstrate that cell migration viewed as a stochastic process is still compatible with biological and experimental observations without the need to rely on more complicated or sophisticated models proposed previously in the literature.

Indexed as

Cell CommunicationCell MovementModels, BiologicalAlgorithmsAnimalsBacterial AdhesionBlood Flow VelocityDiffusionHumansOscillometryOsteoclastsSignal TransductionStochastic Processes

Identifiers

PMID30595832
PMCPMC6286760

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.