Evidence map›Paper›PMID 30595826›Full record

ReviewInternational journal of hematology-oncology and stem cell research2018

Concise Review on Clinical Applications of Conditioned Medium Derived from Human Umbilical Cord-Mesenchymal Stem Cells (UC-MSCs).

Sushmitha Sriramulu, Antara Banerjee, Rosa Di Liddo, Ganesan Jothimani, Madhumala Gopinath, Ramachandran Murugesan, Francesco Marotta, Surajit Pathak

Abstract readReview
PubMed Full text at PMC
In one paragraph

Review in International journal of hematology-oncology and stem cell research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Sushmitha SriramuluFaculty of Allied Health Sciences, Chettinad Hospital & Research Institute(CHRI), Chettinad Academy of Research and Education(CARE), Kelambakkam, Chennai, 603 103, India.
Antara BanerjeeFaculty of Allied Health Sciences, Chettinad Hospital & Research Institute(CHRI), Chettinad Academy of Research and Education(CARE), Kelambakkam, Chennai, 603 103, India.
Rosa Di LiddoDepartment of Pharmaceutical and Pharmacological Sciences, University of Padova, Padova, Italy.
Ganesan JothimaniFaculty of Allied Health Sciences, Chettinad Hospital & Research Institute(CHRI), Chettinad Academy of Research and Education(CARE), Kelambakkam, Chennai, 603 103, India.
Madhumala GopinathFaculty of Allied Health Sciences, Chettinad Hospital & Research Institute(CHRI), Chettinad Academy of Research and Education(CARE), Kelambakkam, Chennai, 603 103, India.
Ramachandran MurugesanFaculty of Allied Health Sciences, Chettinad Hospital & Research Institute(CHRI), Chettinad Academy of Research and Education(CARE), Kelambakkam, Chennai, 603 103, India.
Francesco MarottaReGenera R&D International for Aging Intervention, Milano-Beijing, Italy-China, VCC Preventive Medical Promotion Foundation, Beijing, China.
Surajit PathakFaculty of Allied Health Sciences, Chettinad Hospital & Research Institute(CHRI), Chettinad Academy of Research and Education(CARE), Kelambakkam, Chennai, 603 103, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In recent years, mesenchymal stem cells have provoked much attentiveness in the field of regenerative medicine because of their differentiation potential and the capability to facilitate tissue repair via the emancipation of biologically active molecules. They have gained interest because of their distinctive curative properties. Mesenchymal stem cells are isolated from the Wharton's jelly part of umbilical cord possessing higher proliferation capacity, immunomodulatory activity, plasticity, as well as self-renewal capacity than the mesenchymal stem cells from various origins, and it is considered to be the best resource for allogeneic transplantation. The isolated umbilical cord-derived mesenchymal stem cells are cultured in the Dulbecco's Modified Eagle's Medium, and thereby it begins to release soluble factors into the medium during the period of culture which is termed as conditioned medium. This conditioned media has both differentiation capacity and therapeutic functions. Thus, it can be able to differentiate the cells into different lineages and the paracrine effect of these cells helps in replacement of the damaged cells. This medium may accord to optimization of diagnostic and prognostic systems as well as the generation of novel and targeted therapeutic perspectives.

Indexed as

Conditioned mediumIsolationStem cellsTherapeuticsUmbilical cord

Identifiers

PMID30595826
PMCPMC6305261

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.