Evidence map›Paper›PMID 30595817›Full record

ArticleInternational journal of hematology-oncology and stem cell research2018

Cultured Cells Isolated from CNS Indolent B-Cell Lymphoma Have Characteristics of Mesenchymal Stem Cells: A Clinical Case and Scientific Research.

Kalina Tumagelova-Yuzeir, Ekaterina Ivanova-Todorova, Emanuil Naydenov, Tsvetelina Velikova, Ekaterina Krasimirova, Kalina Belemezova, Tihomir Dikov, Marin Penkov, Sevdalin Nachev, Margarita Genova and 1 more

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PubMed Full text at PMC
In one paragraph

Article in International journal of hematology-oncology and stem cell research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 100% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 1 country.

Kalina Tumagelova-YuzeirLaboratory of Clinical Immunology, University Hospital "St. Ivan Rilski", Department of Clinical Laboratory and Clinical Immunology, Medical University of Sofia, Sofia, Bulgaria.
Ekaterina Ivanova-TodorovaLaboratory of Clinical Immunology, University Hospital "St. Ivan Rilski", Department of Clinical Laboratory and Clinical Immunology, Medical University of Sofia, Sofia, Bulgaria.
Emanuil NaydenovClinic of Neurosurgery, University Hospital "St. Ivan Rilski", Sofia, Bulgaria.
Tsvetelina VelikovaLaboratory of Clinical Immunology, University Hospital "St. Ivan Rilski", Department of Clinical Laboratory and Clinical Immunology, Medical University of Sofia, Sofia, Bulgaria.
Ekaterina KrasimirovaLaboratory of Clinical Immunology, University Hospital "St. Ivan Rilski", Department of Clinical Laboratory and Clinical Immunology, Medical University of Sofia, Sofia, Bulgaria.
Kalina BelemezovaTissue Bank "BulGen", Sofia, Bulgaria.
Tihomir DikovLaboratory of Hematopathology and Immunology, National Specialized Hospital for Active Treatment of Hematological Diseases, Sofia, Bulgaria.
Marin PenkovDepartment of CT and MRI, University Hospital "St. Ivan Rilski", Sofia, Bulgaria.
Sevdalin NachevLaboratory of Neuropathology, University Hospital "St. Ivan Rilski", Sofia, Bulgaria.
Margarita GenovaLaboratory of Hematopathology and Immunology, National Specialized Hospital for Active Treatment of Hematological Diseases, Sofia, Bulgaria.
Dobroslav KyurkchievLaboratory of Clinical Immunology, University Hospital "St. Ivan Rilski", Department of Clinical Laboratory and Clinical Immunology, Medical University of Sofia, Sofia, Bulgaria.
University Hospital St. Ivan Rilski · BGNational Specialized Hospital for Active Treatment of Hematologic Diseases · BGBulgarian National Bank · BGMedical University of Sofia · BG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The case report presented here describes the culturing and characterization of mesenchymal stem cells (MSCs) isolated from a primary indolent B-cell lymphoma, located in the CNS of an immunocompetent patient. The presence of such cells in the tumor mass can further elucidate the pathogenesis of the disease and reveal possible future approaches for its treatment. We present a case report of a 61-year-old immunocompetent woman who had an episode of confusion with numbness in the right leg and the right arm, slurred and dysarthric speech and urine incontinence. The peripheral blood tests were normal. The neurological examination demonstrated a latent hemi-paresis of the right side, aphasia, discrete hypertension and bradypsychia. The ophthalmologic examination revealed left quadranopsia. Computed tomography and magnetic resonance imaging of the brain showed a 3.5 × 2.9 cm infiltrative neoplastic lesion involving the left temporal parenchyma. The morphological features and the immunophenotyping of the lymphoid cell composition were consistent with low-grade (indolent) B-lymphocyte non-Hodgkin's lymphoma of CNS. Cells, isolated from the resected tumor mass, were cultured

Indexed as

CNS lymphomaImmunomodulationIndolent B-cell lymphomaMesenchymal stem cells

Identifiers

PMID30595817
PMCPMC6305270
OpenAlexW2589308187

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.