ArticleThe Egyptian journal of neurology, psychiatry and neurosurgery2018
Insulin-Like Growth Factor-1 in Acute Ischemic Stroke.
Article in The Egyptian journal of neurology, psychiatry and neurosurgery, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 2 of them syntheses that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
6 citing papers in PubMed, 2 syntheses or guidelines pooled it, 15 citations in OpenAlex.
- Relationship between serum insulin-like growth factor 1 levels and ischaemic stroke: a systematic review and meta-analysis.BMJ open · 2022Pooled it
- TNF-α (G-308A) Polymorphism, Circulating Levels of TNF-α and IGF-1: Risk Factors for Ischemic Stroke-An Updated Meta-Analysis.Frontiers in aging neuroscience · 2022Pooled it
- Reversible cerebral vasoconstriction syndrome due to teprotumumab: two case reports.Oxford medical case reports · 2024Article
- MRSL: a causal network pruning algorithm based on GWAS summary data.Briefings in bioinformatics · 2024Article
- Preclinical and clinical evidence of IGF-1 as a prognostic marker and acute intervention with ischemic stroke.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2021Article
- Association between Serum Insulin-Like Growth Factor-1 and Neurological Severity in Acute Ischemic Stroke.Journal of clinical neurology (Seoul, Korea) · 2021Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCerebrovascular ischemic stroke is highly prevalent in the general population and is considered one of the frequent causes of mortality and disability. Insulin-like growth factor-1 (IGF-1) is recognized as an important neuro-protective factor against cerebral vascular ischemic insult. AIM OF THE WORK: To study the relationship between serum IGF-1 levels and acute ischemic stroke (AIS) in the Egyptian population. PATIENTS AND
methodsTwo hundred patients with AIS (within the first 24 h) were subjected to full neurological examination, assessment of stroke severity using National Institute of Health Stroke Scale (NIHSS) and measurement of serum IGF-1 levels. The control group included 100 subjects matched for age, gender, and conventional vascular risk factors.
resultsSerum IGF-1 levels were significantly reduced in cases of first AIS compared to control group. A reduced serum IGF-1 level was an independent risk factor for ischemic stroke with cut off value less than 148.3 ng/ml associated with increased AIS risk.
conclusionLower IGF-1 levels are significantly related to risk of ischemic stroke occurrence, independent from other conventional risk factors in the Egyptian population.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.