Evidence map›Paper›PMID 30595554›Full record

ArticleCell host & microbe2019

A Phytophthora Effector Suppresses Trans-Kingdom RNAi to Promote Disease Susceptibility.

Yingnan Hou, Yi Zhai, Li Feng, Hana Z Karimi, Brian D Rutter, Liping Zeng, Du Seok Choi, Bailong Zhang, Weifeng Gu, Xuemei Chen and 4 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell host & microbe, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 123 papers.

0numbers the graph read from it
0cells of the map it votes in
123citing papers in PubMed
31.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

123 citing papers in PubMed, 253 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. RNA regulation in plants.Science China. Life sciences · 2026
    Review
  5. Article
  6. Review
  7. Article
  8. Review
  9. Article
  10. Review
  11. Review
  12. Review
  13. Review
  14. Article
  15. Stage-Specific Lipidomes ofInternational journal of molecular sciences · 2025
    Article
  16. Review
  17. Article
  18. Epigenetics in the modern era of crop improvements.Science China. Life sciences · 2025
    Review
  19. Article
  20. Article

63 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 2 countries.

Yingnan HouDepartment of Microbiology and Plant Pathology, University of California, Riverside, Riverside, CA 92521, USA; Center for Plant Cell Biology, University of California, Riverside, Riverside, CA 92521, USA.
Yi ZhaiDepartment of Microbiology and Plant Pathology, University of California, Riverside, Riverside, CA 92521, USA; Center for Plant Cell Biology, University of California, Riverside, Riverside, CA 92521, USA.
Li FengInstitute of Plant and Food Science, Department of Biology, Southern University of Science and Technology, Shenzhen 518055, China.
Hana Z KarimiDepartment of Biology, Indiana University, Bloomington, IN 47405, USA.
Brian D RutterDepartment of Biology, Indiana University, Bloomington, IN 47405, USA.
Liping ZengDepartment of Microbiology and Plant Pathology, University of California, Riverside, Riverside, CA 92521, USA; Center for Plant Cell Biology, University of California, Riverside, Riverside, CA 92521, USA.
Du Seok ChoiDepartment of Microbiology and Plant Pathology, University of California, Riverside, Riverside, CA 92521, USA; Center for Plant Cell Biology, University of California, Riverside, Riverside, CA 92521, USA.
Bailong ZhangCenter for Plant Cell Biology, University of California, Riverside, Riverside, CA 92521, USA; Department of Botany and Plant Science, University of California, Riverside, Riverside, CA 92521, USA.
Weifeng GuDepartment of Cell Biology and Neuroscience, University of California, Riverside, Riverside, CA 92521, USA.
Xuemei ChenCenter for Plant Cell Biology, University of California, Riverside, Riverside, CA 92521, USA; Department of Botany and Plant Science, University of California, Riverside, Riverside, CA 92521, USA.
Wenwu YeDepartment of Plant Pathology, Nanjing Agricultural University, Nanjing 210095, China.
Roger W InnesDepartment of Biology, Indiana University, Bloomington, IN 47405, USA.
Jixian ZhaiInstitute of Plant and Food Science, Department of Biology, Southern University of Science and Technology, Shenzhen 518055, China.
Wenbo MaDepartment of Microbiology and Plant Pathology, University of California, Riverside, Riverside, CA 92521, USA; Center for Plant Cell Biology, University of California, Riverside, Riverside, CA 92521, USA. Electronic address: wenbo.ma@ucr.edu.
University of California, Riverside · USIndiana University Bloomington · USSouthern University of Science and Technology · CNNanjing Agricultural University · CN

Funding

Role of microtubules in the non-cell autonomous activities of plant microRNAsR01GM129373 · NIGMS · UNIVERSITY OF CALIFORNIA RIVERSIDE · PI CHEN, XUEMEI · 2018 to 2021
$1.2M
NIGMS NIH HHS R01 GM129373
6 · The paper itself

Abstract

RNA silencing (RNAi) has a well-established role in anti-viral immunity in plants. The destructive eukaryotic pathogen Phytophthora encodes suppressors of RNAi (PSRs), which enhance plant susceptibility. However, the role of small RNAs in defense against eukaryotic pathogens is unclear. Here, we show that Phytophthora infection of Arabidopsis leads to increased production of a diverse pool of secondary small interfering RNAs (siRNAs). Instead of regulating endogenous plant genes, these siRNAs are found in extracellular vesicles and likely silence target genes in Phytophthora during natural infection. Introduction of a plant siRNA in Phytophthora leads to developmental deficiency and abolishes virulence, while Arabidopsis mutants defective in secondary siRNA biogenesis are hypersusceptible. Notably, Phytophthora effector PSR2 specifically inhibits secondary siRNA biogenesis in Arabidopsis and promotes infection. These findings uncover the role of siRNAs as antimicrobial agents against eukaryotic pathogens and highlight a defense/counter-defense arms race centered on trans-kingdom gene silencing between hosts and pathogens.

Indexed as

ArabidopsisArabidopsis ProteinsDisease SusceptibilityGene Expression Regulation, PlantGene SilencingGenes, ReporterHost-Pathogen InteractionsMicroRNAsNicotianaPhosphoprotein PhosphatasesPhytophthoraPlant DiseasesPlant ImmunityPlant LeavesRNA-Binding ProteinsRNA InterferenceArabidopsis ProteinsDRB4 protein, ArabidopsisMicroRNAspentatricopeptide repeat protein, ArabidopsisPhosphoprotein PhosphatasesRNA-Binding ProteinsRNA, Small InterferingVirulence Factorshost-induced gene silencingmicroRNApathogenesisplant immunityRNA interferenceRNA-silencing suppressorsecondary small RNAsvirulence factor

Identifiers

PMID30595554
PMCPMC9208300
OpenAlexW2907183438

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.