Evidence map›Paper›PMID 30595254›Full record

ArticleIndian heart journal2018

Prevalence, risk factors, and significance of iron deficiency and anemia in nonischemic heart failure patients with reduced ejection fraction from a Himachal Pradesh heart failure registry.

P C Negi, Munish Dev, Prince Paul, Davinder Pal Singh, Sanjay Rathoure, Ritesh Kumar, Ashish Dhiman, Arvind Kandoria, Neeraj Ganju, Rajesh Sharma and 6 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Indian heart journal, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
0.7field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 1 institution in 1 country.

P C NegiIGMC Shimla, HP, India. Electronic address: Negiprakash59@gmail.com.
Munish DevIGMC Shimla, HP, India.
Prince PaulIGMC Shimla, HP, India.
Davinder Pal SinghIGMC Shimla, HP, India.
Sanjay RathoureIGMC Shimla, HP, India.
Ritesh KumarIGMC Shimla, HP, India.
Ashish DhimanIGMC Shimla, HP, India.
Arvind KandoriaIGMC Shimla, HP, India.
Neeraj GanjuIGMC Shimla, HP, India.
Rajesh SharmaIGMC Shimla, HP, India.
Rajeev BhardwajIGMC Shimla, HP, India.
Rajeev MerwahaIGMC Shimla, HP, India.
Sanjeev AsotraIGMC Shimla, HP, India.
Kunal MahajanIGMC Shimla, HP, India.
Sachin SondhiIGMC Shimla, HP, India.
Shivani RaoIGMC Shimla, HP, India.
Indira Gandhi Medical College · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe study aimed to estimate the prevalence, risk determinants, and its clinical significance of iron deficiency and anemia in patients of nonischemic heart failure with reduced ejection fraction (HFrEF).

methodsSerum ferritin, transferrin saturation, and the hemoglobin (Hb) levels were measured in 226 consecutive patients with HFrEF diagnosed based on the left ventricular ejection fraction ≤ 45% and absence of coronary artery luminal narrowing of more than 50%, in a prospective tertiary care hospital-based heart failure registry. Patients with the New York Heart Association functional class III/IV were classified as patients with advanced heart failure. Multivariable logistic regression modeling was performed to assess the risk determinants of iron deficiency and anemia and their clinical significance as the risk factors for advanced heart failure. Odds ratio with 95% confidence interval (CI) was reported as the estimates of the strength of association between exposure and outcome variables.

resultsIron deficiency and anemia were prevalent in 58.8% (52.2%-65.1%) and 35.8% (29.8%-42.3%) of patients, respectively. Female gender [OR 3.5 (95% CI 1.9-6.5)], history of bleeding [OR 11.7 (95% CI 1.4-101.2)], and vegetarian diet [OR 2.5 (95% CI 1.4-4.6)] were significantly associated with iron deficiency, while diabetes [OR 3.0 (95% CI 1.40-6.5)], estimated glomerular filtration rate [OR 0.98 (95% CI 0.97-0.99)], history of bleeding [OR 13.0 (95% CI 2.3-70.9)], and female gender [OR 2.9 (95% CI 1.5-5.7)] had significant association with anemia. The Hb level (OR 0.82 (95% CI 0.70-0.96) and transferrin saturation (OR 0.98 (95% CI 0.96-0.99)] had a significant inverse association with symptoms of advanced heart failure.

conclusionIron deficiency and anemia are common comorbidities associated with HFrEF. Low Hb and transferrin saturation are significantly associated with advanced heart failure. The findings have important implications in the management of heart failure.

Indexed as

RegistriesRisk AssessmentAnemia, Iron-DeficiencyExercise ToleranceFemaleFollow-Up StudiesHeart FailureHumansIndiaMaleMiddle AgedPrevalenceProspective StudiesRisk FactorsStroke VolumeVentricular Function, LeftAdvanced heart failureAnemiaHeart failure with reduced ejection fractionIron deficiencyNonischemic systolic heart failureRisk factor

Identifiers

PMID30595254
PMCPMC6310070
OpenAlexW2899330197

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.