Evidence map›Paper›PMID 30595231›Full record

SynthesisBiological psychiatry2019

Error Processing and Inhibitory Control in Obsessive-Compulsive Disorder: A Meta-analysis Using Statistical Parametric Maps.

Luke J Norman, Stephan F Taylor, Yanni Liu, Joaquim Radua, Yann Chye, Stella J De Wit, Chaim Huyser, F Isik Karahanoglu, Tracy Luks, Dara Manoach and 6 more

Abstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Biological psychiatry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 93 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
93citing papers in PubMed, 5 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

93 citing papers in PubMed, 5 syntheses or guidelines pooled it.

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33 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Luke J NormanDepartment of Psychiatry, Michigan Medicine, University of Michigan, Ann Arbor, Michigan; Department of Child and Adolescent Psychiatry, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK. Electronic address: luken@umich.edu.
Stephan F TaylorDepartment of Psychiatry, Michigan Medicine, University of Michigan, Ann Arbor, Michigan.
Yanni LiuDepartment of Psychiatry, Michigan Medicine, University of Michigan, Ann Arbor, Michigan.
Joaquim RaduaDepartment of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK; Institut d'Investigacions Biomèdiques August Pi i Sunyer, Mental Health Research Networking Center, Barcelona, Spain; Centre for Psychiatric Research and Education, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.
Yann ChyeBrain and Mental Health Research Hub, Monash Institute of Cognitive and Clinical Neurosciences, School of Psychological Sciences, Monash University, Melbourne, Australia.
Stella J De WitAmsterdam Neuroscience, Amsterdam University Medical Centers, Department of Psychiatry, Amsterdam, The Netherlands; Department of Anatomy & Neurosciences, Vrije Universiteit, GGZ inGeest Specialized Mental Health Care, Amsterdam, The Netherlands.
Chaim HuyserBascule, Academic Centre for Children and Adolescent Psychiatry, Amsterdam, The Netherlands.
F Isik KarahanogluDepartment of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.
Tracy LuksDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, California.
Dara ManoachDepartment of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts; Athinoula A. Martinos Center for Biomedical Imaging, Charlestown, Massachusetts.
Carol MathewsDepartment of Psychiatry and Center for OCD, Anxiety and Related Disorders, University of Florida, Gainesville, Florida.
Katya RubiaDepartment of Child and Adolescent Psychiatry, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
Chao SuoBrain and Mental Health Research Hub, Monash Institute of Cognitive and Clinical Neurosciences, School of Psychological Sciences, Monash University, Melbourne, Australia.
Odile A van den HeuvelAmsterdam Neuroscience, Amsterdam University Medical Centers, Department of Psychiatry, Amsterdam, The Netherlands; OCD Team, Haukeland University Hospital, Bergen, Norway.
Murat YücelBrain and Mental Health Research Hub, Monash Institute of Cognitive and Clinical Neurosciences, School of Psychological Sciences, Monash University, Melbourne, Australia; Melbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne, Melbourne, Australia.
Kate FitzgeraldDepartment of Psychiatry, Michigan Medicine, University of Michigan, Ann Arbor, Michigan.

Funding

Neurocircuit mechanisms of OCD across the lifespanR01MH102242 · NIMH · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI FITZGERALD, KATE DIMOND, TAYLOR, STEPHAN F · 2014 to 2018
$3.3M
NIMH NIH HHS R01 MH102242
6 · The paper itself

Abstract

backgroundError processing and inhibitory control enable the adjustment of behaviors to meet task demands. Functional magnetic resonance imaging studies report brain activation abnormalities in patients with obsessive-compulsive disorder (OCD) during both processes. However, conclusions are limited by inconsistencies in the literature and small sample sizes. Therefore, the aim here was to perform a meta-analysis of the existing literature using unthresholded statistical maps from previous studies.

methodsA voxelwise seed-based d mapping meta-analysis was performed using t-maps from studies comparing patients with OCD and healthy control subjects (HCs) during error processing and inhibitory control. For the error processing analysis, 239 patients with OCD (120 male; 79 medicated) and 229 HCs (129 male) were included, while the inhibitory control analysis included 245 patients with OCD (120 male; 91 medicated) and 239 HCs (135 male).

resultsPatients with OCD, relative to HCs, showed longer inhibitory control reaction time (standardized mean difference = 0.20, p = .03, 95% confidence interval = 0.016, 0.393) and more inhibitory control errors (standardized mean difference = 0.22, p = .02, 95% confidence interval = 0.039, 0.399). In the brain, patients showed hyperactivation in the bilateral dorsal anterior cingulate cortex, supplementary motor area, and pre-supplementary motor area as well as right anterior insula/frontal operculum and anterior lateral prefrontal cortex during error processing but showed hypoactivation during inhibitory control in the rostral and ventral anterior cingulate cortices and bilateral thalamus/caudate, as well as the right anterior insula/frontal operculum, supramarginal gyrus, and medial orbitofrontal cortex (all seed-based d mapping z value >2, p < .001).

conclusionsA hyperactive error processing mechanism in conjunction with impairments in implementing inhibitory control may underlie deficits in stopping unwanted compulsive behaviors in the disorder.

Indexed as

Inhibition, PsychologicalAdolescentAdultBrainBrain MappingFemaleHumansMagnetic Resonance ImagingMaleNeural PathwaysObsessive-Compulsive DisorderYoung AdultError processingfMRIInhibitory controlMeta-analysisOCDPerformance monitoring

Identifiers

PMID30595231
PMCPMC6474799

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.