ArticleNeurorehabilitation and neural repair2019
Compensation or Recovery? Altered Kinetics and Neuromuscular Synergies Following High-Intensity Stepping Training Poststroke.
Article in Neurorehabilitation and neural repair, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 33 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Robotic Exosuit Augmented Locomotion (REAL) in the Clinic and Community
Robotic Exosuit Augmented Locomotion (REAL) in the Clinic and Community - a Mechanistic Clinical Trial
Wearable Gait Interventions for Augmenting Paretic Propulsion: Towards Personalized Post-Stroke Gait Rehabilitation
Who cites it
33 citing papers in PubMed.
- Higher Intensity Walking Training in Individuals With Chronic Motor Incomplete Spinal Cord Injury: A Randomized Clinical Trial.Neurorehabilitation and neural repair · 2026Trial
- Effects of maximal speed locomotor training on spatiotemporal gait changes in individuals with chronic stroke: A secondary analysis of a randomized controlled trial.Gait & posture · 2025Trial
- Comparative Efficacy of High-Intensity Training Versus Conventional Training in Individuals With Chronic Traumatic Brain Injury: A Pilot Randomized Controlled Study.Journal of neurotrauma · 2024Trial
- Efficacy of an exoskeleton-based physical therapy program for non-ambulatory patients during subacute stroke rehabilitation: a randomized controlled trial.Journal of neuroengineering and rehabilitation · 2021Trial
- Cortical priming strategies for gait training after stroke: a controlled, stratified trial.Journal of neuroengineering and rehabilitation · 2020Trial
- Contributions of Stepping Intensity and Variability to Mobility in Individuals Poststroke.Stroke · 2019Trial
- The Concept of Shaping Applied to Locomotor Interventions: Clinical and Robotic Strategies to Facilitate and Progress Variable Stepping Training at Higher Intensities.Neurorehabilitation and neural repair · 2026Review
- The Differential Effects of Fast Walking Speed on Muscle Coactivation in the Paretic and Non-Paretic Extremities Post-Stroke.Neurorehabilitation and neural repair · 2026Article
- A Longitudinal Study of Physical Function Factors Related to Lower Limb Circumduction During Gait in Acute Stroke Patients with Hemiparesis.Sensors (Basel, Switzerland) · 2025Article
- Taking the Next Step in Neurologic Rehabilitation: Contributions of Intensity and Variability of Stepping Tasks During Locomotor Training.Physical therapy · 2025Review
- Motor modules are largely unaffected by pathological walking biomechanics: a simulation study.Journal of neuroengineering and rehabilitation · 2025Article
- Cortical drive may facilitate enhanced use of the paretic leg induced by random constraint force to the non-paretic leg during walking in chronic stroke.Experimental brain research · 2024Article
- Enhanced phasic calf muscle activation with swing resistance enhances propulsion of the paretic leg in people poststroke.Journal of neurophysiology · 2024Article
- Dynamical network-based evaluation for neuromuscular dysfunction in stroke-induced hemiplegia during standing.Journal of neuroengineering and rehabilitation · 2024Article
- Article
- Restoring natural upper limb movement through a wrist prosthetic module for partial hand amputees.Journal of neuroengineering and rehabilitation · 2023Article
- Overground walking with a constraint force on the nonparetic leg during swing improves weight shift toward the paretic side in people after stroke.Journal of neurophysiology · 2023Article
- Muscle synergies for evaluating upper limb in clinical applications: A systematic review.Heliyon · 2023Review
- Enhanced phasic sensory afferents paired with controlled constraint force improve weight shift toward the paretic side in individuals post-stroke.Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association · 2023Article
- Classification of gait phases based on a machine learning approach using muscle synergy.Frontiers in human neuroscience · 2023Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
backgroundHigh-intensity, variable stepping training can improve walking speed in individuals poststroke, although neuromuscular strategies used to achieve faster speeds are unclear. We evaluated changes in joint kinetics and neuromuscular coordination following such training; movement strategies consistent with intact individuals were considered evidence of recovery and abnormal strategies indicative of compensation.
methodsA total of 15 individuals with stroke (duration: 23 ± 30 months) received ≤40 sessions of high-intensity stepping in variable contexts (tasks and environments). Lower-extremity kinetics and electromyographic (EMG) activity were collected prior to (BSL) and following (POST) training at peak treadmill speeds and speeds matched to peak BSL (MATCH). Primary measures included positive (concentric) joint and total limb powers, measures of interlimb (paretic/nonparetic powers) and intralimb compensation (hip/ankle or knee/ankle powers), and muscle synergies calculated using nonnegative matrix factorization.
resultsGains in most positive paretic and nonparetic joint powers were observed at higher speeds at POST, with decreased interlimb compensation and limited changes in intralimb compensation. There were very few differences in kinetic measures between BSL to MATCH conditions. However, the number of neuromuscular synergies increased significantly following training at both POST and MATCH conditions, indicating gains from training rather than altered speeds. Despite these results, speed improvements were associated primarily with changes in nonparetic versus paretic powers.
conclusionGains in locomotor function were accomplished by movement strategies consistent with both recovery and compensation. These and other data indicate that both strategies may be necessary to maximize walking function in patients poststroke.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.